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1
Thiazolidinediones as anti-cancer agents.噻唑烷二酮类作为抗癌药物。
Cancer Ther. 2008;6(A):25-34.
2
Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.噻唑烷二酮激活过氧化物酶体增殖物激活受体γ可增强线粒体电位并促进细胞存活。
J Biol Chem. 2002 Aug 30;277(35):31781-8. doi: 10.1074/jbc.M204279200. Epub 2002 Jun 24.
3
Thiazolidinedione derivatives in cancer therapy: exploring novel mechanisms, therapeutic potentials, and future horizons in oncology.噻唑烷二酮衍生物在癌症治疗中的应用：探索肿瘤学中的新机制、治疗潜力及未来前景
Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):4705-4725. doi: 10.1007/s00210-024-03661-z. Epub 2024 Dec 2.
4
Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?过氧化物酶体增殖物激活受体噻唑烷二酮类激动剂的非受体依赖性作用：线粒体功能是关键吗？
Biochem Pharmacol. 2005 Jul 15;70(2):177-88. doi: 10.1016/j.bcp.2005.03.033.
5
Bone loss in diabetes: use of antidiabetic thiazolidinediones and secondary osteoporosis.糖尿病性骨丢失：噻唑烷二酮类抗糖尿病药物的应用与继发性骨质疏松症。
Curr Osteoporos Rep. 2010 Dec;8(4):178-84. doi: 10.1007/s11914-010-0027-y.
6
Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression.噻唑烷二酮对分离的大鼠骨骼肌燃料处理的直接作用独立于过氧化物酶体增殖物激活受体γ介导的基因表达变化。
Diabetes. 2001 Oct;50(10):2309-15. doi: 10.2337/diabetes.50.10.2309.
7
The mode of action of thiazolidinediones.噻唑烷二酮类药物的作用方式。
Diabetes Metab Res Rev. 2002 Mar-Apr;18 Suppl 2:S10-5. doi: 10.1002/dmrr.249.
8
Possible Protective Effects of Thiazolidinediones Antidiabetic Drugs in Colorectal Cancer.噻唑烷二酮类抗糖尿病药物在结直肠癌中的潜在保护作用。
Crit Rev Oncog. 2019;24(3):251-258. doi: 10.1615/CritRevOncog.2019031265.
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Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.过氧化物酶体增殖物激活受体γ激动剂通过抑制细胞周期蛋白D3和细胞周期停滞来降低生存素水平，从而促进肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的细胞凋亡。
J Biol Chem. 2005 Feb 25;280(8):6742-51. doi: 10.1074/jbc.M411519200. Epub 2004 Nov 29.
10
Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects.噻唑烷二酮是一种过氧化物酶体增殖物激活受体γ配体，通过促进分化作用抑制HT-29人结肠癌细胞的生长和转移。
Int J Oncol. 2004 Sep;25(3):631-9.

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Real-world evidence on the association of novel antidiabetic medication use with cancer risk and protective effects: a systematic review and network meta-analysis.新型抗糖尿病药物使用与癌症风险及保护作用关联的真实世界证据：一项系统综述和网状Meta分析。
Ther Adv Drug Saf. 2025 Apr 21;16:20420986251335214. doi: 10.1177/20420986251335214. eCollection 2025.
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Associations between Diabetes Mellitus and Selected Cancers.糖尿病与某些癌症之间的关联。
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Role of 4-Thiazolidinone-Pyrazoline/Indoline Hybrids Les-4369 and Les-3467 in BJ and A549 Cell Lines.4-噻唑烷-2,4-二酮-吡唑啉/吲哚啉杂合体 Les-4369 和 Les-3467 在 BJ 和 A549 细胞系中的作用。
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本文引用的文献

1
Association between cancer prevalence and use of thiazolidinediones: results from the Vermont Diabetes Information System.癌症患病率与噻唑烷二酮类药物使用之间的关联：来自佛蒙特糖尿病信息系统的结果。
BMC Med. 2007 Jun 21;5:17. doi: 10.1186/1741-7015-5-17.
2
Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation.过氧化物酶体增殖物激活受体γ激活在人非小细胞肺癌中的凋亡作用是通过脯氨酸氧化酶诱导的活性氧形成介导的。
Mol Pharmacol. 2007 Sep;72(3):674-85. doi: 10.1124/mol.107.035584. Epub 2007 May 29.
3
4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells.4-羟基壬烯醛和过氧化物酶体增殖物激活受体γ配体影响结肠癌细胞的增殖、分化和凋亡。
Free Radic Biol Med. 2007 Jun 1;42(11):1661-70. doi: 10.1016/j.freeradbiomed.2007.02.009. Epub 2007 Feb 20.
4
Rosiglitazone enhances fluorouracil-induced apoptosis of HT-29 cells by activating peroxisome proliferator-activated receptor gamma.罗格列酮通过激活过氧化物酶体增殖物激活受体γ增强氟尿嘧啶诱导的HT-29细胞凋亡。
World J Gastroenterol. 2007 Mar 14;13(10):1534-40. doi: 10.3748/wjg.v13.i10.1534.
5
Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes.噻唑烷二酮类药物与糖尿病患者患肺癌、前列腺癌和结肠癌的风险
J Clin Oncol. 2007 Apr 20;25(12):1476-81. doi: 10.1200/JCO.2006.07.2777.
6
Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival.过氧化物酶体增殖物激活受体γ在结肠癌中的表达：与组织病理学参数、细胞周期相关分子及患者生存率的相关性
Dig Dis Sci. 2007 Sep;52(9):2305-11. doi: 10.1007/s10620-007-9794-4. Epub 2007 Mar 28.
7
Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines.过氧化物酶体增殖物激活受体（PPARs）在人结肠癌标本及正常和癌细胞系中的细胞增殖和凋亡中的作用。
PPAR Res. 2007;2007:93416. doi: 10.1155/2007/93416.
8
PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling.噻唑烷二酮类药物（TZDs）激活过氧化物酶体增殖物激活受体γ（PPARγ）可能会调节乳腺癌的预后：与转化生长因子β（TGFβ）信号相互作用的重要性。
J Cell Mol Med. 2007 Jan-Feb;11(1):71-87. doi: 10.1111/j.1582-4934.2007.00003.x.
9
Involvement of PPAR gamma and E-cadherin/beta-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cells.过氧化物酶体增殖物激活受体γ和E-钙黏蛋白/β-连环蛋白通路在共轭亚油酸对MCF-7细胞的抗增殖作用中的参与情况。
Int J Cancer. 2007 Jul 15;121(2):248-56. doi: 10.1002/ijc.22646.
10
Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors.药物洞察：过氧化物酶体增殖物激活受体激动剂的作用机制及治疗应用
Nat Clin Pract Endocrinol Metab. 2007 Feb;3(2):145-56. doi: 10.1038/ncpendmet0397.

噻唑烷二酮类作为抗癌药物。

Thiazolidinediones as anti-cancer agents.

作者信息

Blanquicett Carmelo, Roman Jesse, Hart C Michael

机构信息

Department of Medicine, Emory University and Atlanta Veterans Affairs Medical Centers, Atlanta, GA 30033.

出版信息

Cancer Ther. 2008;6(A):25-34.

PMID:19079765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2600565/
Abstract

The PPAR-gamma (PPAR-γ) activating thiazolidinedione (TZD) medications are a class of drugs used to improve lipid and glucose metabolism in type-2 diabetes. In addition to their known insulin sensitization action, these drugs have been shown to suppress tumor development in several in vitro and in vivo models. Among the proposed mechanisms for the anti-tumor effects of TZDs, apoptosis induction, cell cycle arrest, and differentiation have been extensively reported. Interestingly, some of the observed anti-tumor effects are independent of PPAR-γ activation. The following review will discuss studies employing TZDs as anti-cancer therapies for the most common types of cancers including, lung, breast, and colon and will explore the principal PPAR-γ-dependent and -independent mechanisms by which TZDs exert their anti-tumor effects.

摘要

激活过氧化物酶体增殖物激活受体γ（PPAR-γ）的噻唑烷二酮（TZD）类药物是一类用于改善2型糖尿病患者脂质和葡萄糖代谢的药物。除了已知的胰岛素增敏作用外，这些药物在多种体外和体内模型中均显示出抑制肿瘤发展的作用。在提出的TZD类药物抗肿瘤作用机制中，诱导凋亡、细胞周期阻滞和分化已被广泛报道。有趣的是，一些观察到的抗肿瘤作用独立于PPAR-γ激活。以下综述将讨论使用TZD类药物作为肺癌、乳腺癌和结肠癌等最常见癌症的抗癌疗法的研究，并探讨TZD类药物发挥抗肿瘤作用的主要PPAR-γ依赖性和非依赖性机制。