Chen Yuan-Hang, Li Zhi-Ping
Department of Abdominal Oncology, West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, PR China.
Ai Zheng. 2008 Dec;27(12):1341-4.
The aim of preoperative radiotherapy for rectal cancer is to improve the local control rate, increase the possibility for sphincter preservation, and improve the survival and the quality of life. Randomized clinical trials have shown that combining radical surgery with preoperative radiochemotherapy is more effective in improving the local control rate as compared with radical surgery or preoperative radiotherapy alone. With introduction of more effective novel chemotherapeutic agents and schemes of their combination, multimodal treatment with preoperative radiochemotherapy will be applied individually to treat selected patients, which is expected to further enhance the therapeutic effect of rectal cancer. This article reviewed the current status and development of preoperative radiochemotherapy for rectal cancer.
直肠癌术前放疗的目的是提高局部控制率，增加保留括约肌的可能性，并改善生存率和生活质量。随机临床试验表明，与单纯根治性手术或术前放疗相比，根治性手术联合术前放化疗在提高局部控制率方面更有效。随着更有效的新型化疗药物及其联合方案的引入，术前放化疗的多模式治疗将个体化应用于特定患者，有望进一步提高直肠癌的治疗效果。本文综述了直肠癌术前放化疗的现状及发展。
