Korenjak Michael, Dyson Nicholas
MGH Cancer Center, Charlestown, MA 02129, USA.
Dev Cell. 2008 Dec;15(6):793-4. doi: 10.1016/j.devcel.2008.11.007.
In a paper in this issue of Developmental Cell, Shibutani et al. (2008) uncover the mechanism that underlies tightly regulated S-phase degradation of Drosophila E2F1 during development. They show that dE2F1 is degraded by the Cul4(Cdt2) ubiquitin ligase in a manner that resembles the DNA replication-dependent turnover of Cdt1.
在本期《发育细胞》杂志上发表的一篇论文中，Shibutani等人（2008年）揭示了果蝇E2F1在发育过程中S期严格调控降解的潜在机制。他们表明，dE2F1被Cul4（Cdt2）泛素连接酶降解，其方式类似于Cdt1的DNA复制依赖性周转。
