Hirata A E, Morgan D, Oliveira-Emilio H R, Rocha M S, Carvalho C R O, Curi R, Carpinelli A R
Department of Physiology, Federal University of Sao Paulo-UNIFESP, São Paulo, Brazil.
Regul Pept. 2009 Feb 25;153(1-3):1-6. doi: 10.1016/j.regpep.2008.11.004. Epub 2008 Nov 27.
Angiotensin II (Ang II) controls blood pressure, electrolyte balance, cell growth and vascular remodeling. Ang II activates NAD(P)H oxidase in several tissues with important function in the control of insulin secretion. Considering the concomitant occurrence of hypertension, insulin resistance and pancreatic B cell secretion impairment in the development of type II diabetes the aim of the present study was to evaluate the effect of ANG II on NAD(P)H oxidase activation in isolated pancreatic islets. We found that ANGII-induced superoxide generation via NAD(P)H oxidase activation and increased protein and mRNA levels of NAD(P)H oxidase subunits (p47(PHOX) and gp91(PHOX)).
血管紧张素II（Ang II）控制血压、电解质平衡、细胞生长和血管重塑。Ang II在几个对胰岛素分泌控制具有重要作用的组织中激活NAD(P)H氧化酶。鉴于在II型糖尿病发展过程中高血压、胰岛素抵抗和胰腺β细胞分泌受损同时出现，本研究的目的是评估Ang II对分离的胰岛中NAD(P)H氧化酶激活的影响。我们发现，Ang II通过激活NAD(P)H氧化酶诱导超氧化物生成，并增加了NAD(P)H氧化酶亚基（p47(PHOX)和gp91(PHOX)）的蛋白质和mRNA水平。
