CIAPIN1抑制肾透明细胞癌的生长和增殖。
CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma.
作者信息
He Lijie, Wang Hanmin, Jin Haifeng, Guo Changcun, Xie Huahong, Yan Kun, Li Xiaohuai, Shen Qing, Qiao Taidong, Chen Guanglei, Chai Na, Zhao Lina, Dong Qingchuan, Zheng Yan, Liu Jie, Fan Daiming
机构信息
State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, the Fourth Military Medical University, 17 Changle Western Road, Xi'an 710032, China.
出版信息
Cancer Lett. 2009 Apr 8;276(1):88-94. doi: 10.1016/j.canlet.2008.10.044. Epub 2008 Dec 9.
Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues (P<0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but up-regulation of p27Kip1 and Rb.
我们之前的研究表明，CIAPIN1缺失与人类胃癌的肿瘤发生直接相关。在此我们报告，102例透明细胞肾细胞癌（CCRCC）组织中CIAPIN1表达缺失或显著降低（P<0.05）。通过腺病毒载体上调CIAPIN1在体外和体内均显著抑制CCRCC来源细胞的生长，并使细胞周期停滞于G1期。同时，发现CIAPIN1诱导的生长抑制部分通过调节多种蛋白质来实现，包括抑制细胞周期蛋白D1、细胞周期蛋白E、细胞周期蛋白依赖性激酶2、细胞周期蛋白依赖性激酶4、磷酸化视网膜母细胞瘤蛋白和血管内皮生长因子，但上调p27Kip1和视网膜母细胞瘤蛋白。
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