鸟苷三磷酸环化水解酶基因（GCH1）的多态性与辣椒素疼痛评分相关。
Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain.
作者信息
Campbell Claudia M, Edwards Robert R, Carmona Cheryl, Uhart Magdalena, Wand Gary, Carteret Alene, Kim Yu Kyeong, Frost James, Campbell James N
机构信息
Department of Psychiatry & Behavioral Sciences, The Johns Hopkins University School of Medicine, Meyer 1-108, 600 N Wolfe Street, Baltimore, MD 21287, USA.
出版信息
Pain. 2009 Jan;141(1-2):114-8. doi: 10.1016/j.pain.2008.10.023. Epub 2008 Dec 9.
Abstract
Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Possibly, the effects of single nucleotide polymorphisms (SNPs) vary depending on the pain task. The current investigation analyzed the association of five previously identified GCH1 SNPs with ratings of pain induced by topical high concentration (10%) capsaicin applied to the skin of 39 healthy human volunteers. Each of the GCH1 polymorphisms was associated with lower pain ratings. When combined, three of the five accounted for a surprisingly high 35% of the inter-individual variance in pain ratings. We conclude that SNPs of the GCH1 gene may profoundly affect the ratings of pain induced by capsaicin.
摘要
尽管基因组变异性在解释疼痛敏感性方面显然起着不可或缺的作用，但对于涉及哪些基因存在争议。虽然最近的数据表明，鸟苷三磷酸环化水解酶（GCH1）基因存在一种“保护性”（即疼痛较轻）单倍型，但其他研究未能证实这种关联。单核苷酸多态性（SNP）的影响可能因疼痛任务而异。当前的研究分析了五个先前确定的GCH1 SNP与局部应用高浓度（10%）辣椒素诱发的疼痛评分之间的关联，该辣椒素应用于39名健康人类志愿者的皮肤。每个GCH1多态性都与较低的疼痛评分相关。综合起来，五个中的三个在个体间疼痛评分差异中占了惊人的35%。我们得出结论，GCH1基因的SNP可能会深刻影响辣椒素诱发的疼痛评分。
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