挪威胰岛素依赖型糖尿病患者中HLA-DRB1、-DQA1和-DQB1等位基因以及DQA1-DQB1基因型的分布情况。

Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus.

作者信息

Rønningen K S, Spurkland A, Iwe T, Vartdal F, Thorsby E

机构信息

Institute of Transplantation Immunology, National Hospital, Oslo, Norway.

出版信息

Tissue Antigens. 1991 Mar;37(3):105-11. doi: 10.1111/j.1399-0039.1991.tb01854.x.

DOI:10.1111/j.1399-0039.1991.tb01854.x

PMID:1908143

Abstract

We have studied 87 unrelated Caucasian insulin-dependent diabetes mellitus (IDDM) patients and 181 healthy controls by oligotyping for 20 DRB1, eight DQA1 and 13 DQB1 alleles, and established their DR-DQ haplotypes and DQ genotypes. An increase of DRB1 alleles encoding DR4 was found among IDDM patients, but the distribution of DR4 subtypes did not differ among DR4-positive IDDM patients and controls. The frequency of certain DRB1-DQA1-DQB1 haplotypes and DQA1-DQB1 genotypes was significantly increased among IDDM patients. Taken together, the data suggest that IDDM is primarily associated with several (at least five) different DQ alpha beta heterodimers.

摘要

我们通过对20个DRB1、8个DQA1和13个DQB1等位基因进行寡核苷酸分型，研究了87名无亲缘关系的高加索胰岛素依赖型糖尿病（IDDM）患者和181名健康对照，并确定了他们的DR-DQ单倍型和DQ基因型。在IDDM患者中发现编码DR4的DRB1等位基因增加，但DR4亚型在DR4阳性的IDDM患者和对照中的分布没有差异。某些DRB1-DQA1-DQB1单倍型和DQA1-DQB1基因型的频率在IDDM患者中显著增加。综合来看，数据表明IDDM主要与几种（至少五种）不同的DQαβ异二聚体相关。