津巴布韦黑人胰岛素依赖型糖尿病患者及对照人群中HLA - DQA1、- DQB1和DRB1等位基因的分布情况。

Distribution of HLA-DQA1, -DQB1 and DRB1 alleles in black IDDM patients and controls from Zimbabwe.

作者信息

Garcia-Pacheco J M, Herbut B, Cutbush S, Hitman G A, Zhonglin W, Magzoub M, Bottazzo G F, Kiere C, West G, Mvere D

机构信息

Department of Immunology, London Hospital Medical College, U.K.

出版信息

Tissue Antigens. 1992 Sep;40(3):145-9. doi: 10.1111/j.1399-0039.1992.tb02107.x.

DOI:10.1111/j.1399-0039.1992.tb02107.x

PMID:1440568

Abstract

We have used the XI Histocompatibility Workshop sequence-specific oligonucleotide probes to determine the DRB1, DQA1 and DQB1 genotypes by dot-blot hybridization of polymerase chain reaction (pcr)-amplified material from a homogenous black population in Zimbabwe. The DR4 subtype DRB10405, the DR3 subtype DRB10301, DQB10201 and DQB10302 and DQA10301 and DQA10501 were significantly increased in the IDDM group compared to the controls, whereas DRB111, DQB10602 and DQA1*0102 were significantly decreased. Taken together, the data show that susceptibility and resistance to IDDM are associated both with particular haplotypes and DQA1-DQB1 heterodimers without one or other being overriding.

摘要

我们使用了第十一届组织相容性研讨会序列特异性寡核苷酸探针，通过对来自津巴布韦一个同质黑人种群的聚合酶链反应（PCR）扩增材料进行点杂交，来确定DRB1、DQA1和DQB1基因型。与对照组相比，IDDM组中DR4亚型DRB10405、DR3亚型DRB10301、DQB10201和DQB10302以及DQA10301和DQA10501显著增加，而DRB111、DQB10602和DQA1*0102则显著减少。总体而言，数据表明，对IDDM的易感性和抗性与特定单倍型以及DQA1 - DQB1异二聚体均相关，且没有一方起主导作用。