Greenberg Gahl, Mikulis David J, Ng Kevin, DeSouza Danielle, Green Robin E
Department of Medical Imaging, Division of Neuroradiology, University Health Network, Toronto, ON, Canada.
Arch Phys Med Rehabil. 2008 Dec;89(12 Suppl):S45-50. doi: 10.1016/j.apmr.2008.08.211.
To demonstrate subacute progression of white matter (WM) injury (4.5mo-2.5y postinjury) in patients with traumatic brain injury using diffusion-tensor imaging.
Prospective, repeated-measures, within-subjects design.
Inpatient neurorehabilitation program and teaching hospital MRI department.
Brain-injured adults (N=13) with a mean Glasgow Coma Scale score of 7.67+/-4.16.
Not applicable.
Fractional anisotropy (FA) values were measured at 4.5 and 29 months postinjury in right and left frontal and temporal deep WM tracts and the anterior and posterior corpus callosum.
FA significantly decreased in frontal and temporal tracts: right frontal (.38+/-.06 to .30+/-.06; P<.005), left frontal (.37+/-.06 to .32+/-.06; P<.05), right temporal (.28+/-.05 to .22+/-.018; P<.005), and left temporal (.28+/-.05 to .24+/-.02; P<.05). No significant changes were in the corpus callosum.
Preliminary results demonstrate progression of WM damage as evidenced by interval changes in diffusion anisotropy. Future research should examine the relationship between decreased FA and long-term clinical outcome.
利用扩散张量成像技术，证明创伤性脑损伤患者白质（WM）损伤的亚急性进展（损伤后4.5个月至2.5年）。
前瞻性、重复测量、受试者内设计。
住院神经康复项目及教学医院MRI科室。
脑损伤成年患者（N = 13），格拉斯哥昏迷量表平均评分为7.67±4.16。
不适用。
在损伤后4.5个月和29个月时，测量左右额叶和颞叶深部白质束以及胼胝体前后部的各向异性分数（FA）值。
额叶和颞叶束的FA显著降低：右侧额叶（从0.38±0.06降至0.30±0.06；P <.005），左侧额叶（从0.37±0.06降至0.32±0.06；P <.05），右侧颞叶（从0.28±0.05降至0.22±0.018；P <.005），左侧颞叶（从0.28±0.05降至0.24±0.02；P <.05）。胼胝体无显著变化。
初步结果表明，扩散各向异性的间隔变化证明了白质损伤的进展。未来的研究应检查FA降低与长期临床结果之间的关系。
