Sordillo L M, Babiuk L A
Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada.
Vet Microbiol. 1991 Jul;28(2):189-98. doi: 10.1016/0378-1135(91)90092-t.
The efficacy of recombinant bovine interferon (rBoIFN)-gamma against experimentally induced Escherichia coli mastitis during the periparturient period was investigated. Dairy cows intramammarily treated with rBoIFN-gamma 24 h before the E. coli challenge had fewer infected quarters, lower clinical scores, and infections of shorter duration when compared to placebo-treated animals. All rBoIFN-gamma treated cows survived the experimental E. coli challenge. However, placebo treated cows had a 42% mortality rate attributed to coliform mastitis within 3 days of the challenge. Results from this study suggest that intramammary infusion of rBoIFN-gamma can prevent the rapid, unrestricted growth of E. coli within the mammary gland and inhibit the subsequent development of an unlimited inflammatory response under experimental conditions. It is likely that controlling severe local inflammatory reactions may also decrease the pathological alterations to mammary parenchymal tissue that often accompanies acute coliform mastitis during the periparturient period. The potential for prophylactic treatment of perinatal dairy cows with rBoIFN-gamma to regulate the rate, severity, and duration of naturally occurring coliform mastitis during periods of heightened susceptibility is discussed.
研究了重组牛干扰素（rBoIFN）-γ对围产期实验性诱导的大肠杆菌性乳腺炎的疗效。与接受安慰剂治疗的动物相比，在大肠杆菌攻击前24小时经乳房内注射rBoIFN-γ的奶牛感染的乳腺区更少，临床评分更低，感染持续时间更短。所有接受rBoIFN-γ治疗的奶牛都在实验性大肠杆菌攻击中存活下来。然而，接受安慰剂治疗的奶牛在攻击后3天内由于大肠菌性乳腺炎的死亡率为42%。这项研究的结果表明，乳房内注入rBoIFN-γ可以在实验条件下防止大肠杆菌在乳腺内快速、无限制地生长，并抑制随后不受控制的炎症反应的发展。控制严重的局部炎症反应也可能减少围产期急性大肠菌性乳腺炎常伴随的乳腺实质组织的病理改变。本文讨论了用rBoIFN-γ对围产期奶牛进行预防性治疗以调节自然发生的大肠菌性乳腺炎在易感性增强期间的发生率、严重程度和持续时间的潜力。
