The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines.
作者信息
Chan Sau Hing, Lam Kim Hung, Chui Chung Hin, Gambari Roberto, Yuen Marcus Chun Wah, Wong Raymond Siu Ming, Cheng Gregory Yin Ming, Lau Fung Yi, Au Yiu Kwok, Cheng Chor Hing, Lai Paul Bo Shan, Kan Chi Wai, Kok Stanton Hon Lung, Tang Johnny Cheuk On, Chan Albert Sun Chi
机构信息
Lo Ka Chung Centre for Natural Anti-cancer Drug Development (Laboratory B), Departement of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University, 852 Hong Kong, China.
出版信息
Eur J Med Chem. 2009 Jun;44(6):2736-40. doi: 10.1016/j.ejmech.2008.10.024. Epub 2008 Nov 5.
The 'one pot' condensation reaction for the synthesis and potent antiproliferative inhibition of alpha-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.
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