Panteleakou Zacharoula, Lembessis Peter, Sourla Antigone, Pissimissis Nikolaos, Polyzos Aristides, Deliveliotis Charalambos, Koutsilieris Michael
Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece.
Mol Med. 2009 Mar-Apr;15(3-4):101-14. doi: 10.2119/molmed.2008.00116. Epub 2008 Dec 3.
Disseminated malignancy is the major cause of prostate cancer-related mortality. Circulating tumor cells (CTCs) are essential for the establishment of metastasis. Various contemporary and molecular methods using prostate-specific biomarkers have been applied to detect extraprostatic disease that is undetectable by conventional imaging techniques, assessing the risk for disease recurrence after therapy of curative intent. However, the clinical relevance of CTC detection is still controversial. We review current literature regarding molecular methods used for the detection of CTCs in the peripheral blood and bone marrow biopsies of patients with prostate cancer, and we discuss the methodological pitfalls that influence the clinical significance of molecular staging.
播散性恶性肿瘤是前列腺癌相关死亡的主要原因。循环肿瘤细胞（CTC）对于转移的形成至关重要。已应用各种使用前列腺特异性生物标志物的当代和分子方法来检测常规成像技术无法检测到的前列腺外疾病，评估根治性治疗后疾病复发的风险。然而，CTC检测的临床相关性仍存在争议。我们回顾了有关用于检测前列腺癌患者外周血和骨髓活检中CTC的分子方法的当前文献，并讨论了影响分子分期临床意义的方法学缺陷。
