Anne E. de Papp and Andrew F. Stewart are at the Division of Endocrinology, West Haven Veterans Affairs Medical Center, West Haven, CT 06516, USA; Division of Endocrinology, Yale University School of Medicine, New Haven, CT 06510, USA.
Trends Endocrinol Metab. 1993 Aug;4(6):181-7. doi: 10.1016/1043-2760(93)90114-t.
Parathyroid hormone-related protein (PTHrP) is the factor responsible for the syndrome of humoral hypercalcemia of malignancy. PTHrP is produced by a multitude o f normal as well as malignant cells, and exerts both classic parathyroid hormone (PTH)-like and PTH-unlike effects. The molecular cloning of the PTHrP gene, and the subsequent recognition of its widespread expression in normal tissues under normal physiologic conditions, has prompted intense inquiry into its biologic function. PTHrP appears to act in an autocrine or paracrine fashion in (a) normal embryogenesis and neonatal development, (b) cellular growth and differentiation, (c) reproduction and lactation, (d) epithelial calcium transport, and (e) smooth muscle relaxation. These five key emerging physiologic roles of PTHrP are the focus of this review.
甲状旁腺激素相关蛋白 (PTHrP) 是导致恶性肿瘤相关体液性高钙血症综合征的原因。PTHrP 由多种正常和恶性细胞产生，发挥经典甲状旁腺激素 (PTH) 样和非 PTH 样作用。PTHrP 基因的分子克隆，以及随后在正常生理条件下正常组织中广泛表达的认识，促使人们对其生物学功能进行了深入研究。PTHrP 似乎以自分泌或旁分泌的方式作用于：(a) 正常胚胎发生和新生儿发育，(b) 细胞生长和分化，(c) 生殖和泌乳，(d) 上皮细胞钙转运，和 (e) 平滑肌松弛。PTHrP 的这五个关键的新兴生理作用是本文的重点。
