Speer Colenso M, Chapman Barbara
Center for Neuroscience, University of California, Davis, USA.
Thalamus Relat Syst. 2005 Sep;3(3):235-244. doi: 10.1017/S1472928807000234.
The Eph family of receptor tyrosine kinases and their partner ligands, the ephrins, mediate cell-cell interactions in the developing nervous system. Signaling events between Eph receptors and ephrin ligands on interacting cells affect the growth, maturation, migration and connectivity of individual neurons and neural networks. Here we review the known roles of Eph-ephrin signaling in the development of the thalamus and its connections, and pose new questions for experimental study.
受体酪氨酸激酶的Eph家族及其配体 Ephrin 在发育中的神经系统中介导细胞间相互作用。相互作用细胞上的 Eph 受体和 Ephrin 配体之间的信号事件影响单个神经元和神经网络的生长、成熟、迁移和连接。在这里，我们综述了 Eph-Ephrin 信号在丘脑及其连接发育中的已知作用，并提出了新的实验研究问题。
