Belousoff Matthew J, Graham Bim, Spiccia Leone, Tor Yitzhak
School of Chemistry, Monash University, Clayton, Vic 3800, Australia.
Org Biomol Chem. 2009 Jan 7;7(1):30-3. doi: 10.1039/b813252f. Epub 2008 Oct 30.
A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.
多种氨基糖苷类抗生素，尤其是新霉素B，已被证明可通过与RNA寡核苷酸（最小化的HIV-1 TAR元件和原核核糖体A位点）结合并对RNA主链造成足够的扭曲，使其更易发生分子内酯交换反应，从而促进RNA寡核苷酸的链断裂。
