氨基糖苷类对RNA寡核苷酸的切割作用。
Cleavage of RNA oligonucleotides by aminoglycosides.
作者信息
Belousoff Matthew J, Graham Bim, Spiccia Leone, Tor Yitzhak
机构信息
School of Chemistry, Monash University, Clayton, Vic 3800, Australia.
出版信息
Org Biomol Chem. 2009 Jan 7;7(1):30-3. doi: 10.1039/b813252f. Epub 2008 Oct 30.
DOI:10.1039/b813252f
PMID:19081939
Abstract
A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.
摘要
多种氨基糖苷类抗生素，尤其是新霉素B，已被证明可通过与RNA寡核苷酸（最小化的HIV-1 TAR元件和原核核糖体A位点）结合并对RNA主链造成足够的扭曲，使其更易发生分子内酯交换反应，从而促进RNA寡核苷酸的链断裂。
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