Andersen Casper S, Gothelf Kurt V
Danish National Research Foundation: Centre for DNA Nanotechnology, Department of Chemistry and Interdisciplinary Nanoscience Center, Langelandsgade 140, 8000 Aarhus C, Denmark.
Org Biomol Chem. 2009 Jan 7;7(1):58-60. doi: 10.1039/b815099k. Epub 2008 Nov 5.
We are presenting the synthesis of a phenylene ethynylene-based rod containing an Fmoc protected amino group and an activated acid which can be applied to peptide couplings. This linear amino acid analogue is applied to the synthesis of di-, tri- and pentamers. The pentamer has a molecular mass of 6.5 kDa and is characterized by (1)H NMR spectroscopy and MALDI-TOF MS. The method has potential for the formation of long macromolecular oligomers.
我们展示了一种基于亚苯基乙炔的棒状化合物的合成，该化合物含有一个Fmoc保护的氨基和一个可用于肽偶联的活化酸。这种线性氨基酸类似物被应用于二聚体、三聚体和五聚体的合成。该五聚体的分子量为6.5 kDa，并通过¹H NMR光谱和MALDI-TOF MS进行了表征。该方法具有形成长链大分子低聚物的潜力。
