氨基酸衍生的巯基咪唑。

Aminoacid-derived mercaptoimidazoles.

作者信息

Crépin Alain, Wattier Nicolas, Petit Sylvain, Bischoff Laurent, Fruit Corinne, Marsais Francis

机构信息

Val-de-Pharm, Parc industriel d'Incarville, BP 606, 27106, Val-de-Reuil Cedex, France.

出版信息

Org Biomol Chem. 2009 Jan 7;7(1):128-34. doi: 10.1039/b810678a. Epub 2008 Oct 31.

DOI:10.1039/b810678a

PMID:19081955

Abstract

Starting from suitably protected amino acids, mercaptoimidazoles were synthesized either from the acid or including the amine nitrogen itself. A preliminary optimisation study led to efficient conditions for the obtention of the imidazole ring. These conditions are compatible with the presence of amino acid or dipeptide scaffolds.

摘要

从适当保护的氨基酸出发，巯基咪唑可由酸合成，也可包含胺氮本身进行合成。一项初步的优化研究得出了获得咪唑环的有效条件。这些条件与氨基酸或二肽支架的存在相容。