使用全氟立方倍半硅氧烷包覆的二氧化硅纳米颗粒监测酶活性的多模态¹⁹F核磁共振探针。
Multi-modal 19F NMR probe using perfluorinated cubic silsesquioxane-coated silica nanoparticles for monitoring enzymatic activity.
作者信息
Tanaka Kazuo, Kitamura Narufumi, Naka Kensuke, Chujo Yoshiki
机构信息
Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
出版信息
Chem Commun (Camb). 2008 Dec 14(46):6176-8. doi: 10.1039/b815022b. Epub 2008 Oct 21.
The establishment of (19)F NMR signal regulation and the application of this strategy to develop a multi-modal (19)F NMR probe for monitoring enzymatic activity using nanoparticles as a signal regulator is described; water-soluble perfluorinated cubic silsesquioxane was synthesized and immobilized onto the silica nanoparticles for suppressing the signals; (19)F NMR signals of the probes were recovered by releasing from nanoparticles.
描述了（19）F核磁共振信号调控的建立以及该策略在开发一种多模态（19）F核磁共振探针中的应用，该探针利用纳米颗粒作为信号调节剂来监测酶活性；合成了水溶性全氟立方倍半硅氧烷并将其固定在二氧化硅纳米颗粒上以抑制信号；通过从纳米颗粒中释放来恢复探针的（19）F核磁共振信号。
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