一种用于对映选择性烯丙基取代反应的、含有C2对称亚磷酸酯配体的出色钯体系。
An outstanding palladium system containing a C2-symmetrical phosphite ligand for enantioselective allylic substitution processes.
作者信息
Balanta Castillo Angelica, Favier Isabelle, Teuma Emmanuelle, Castillón Sergio, Godard Cyril, Aghmiz Ali, Claver Carmen, Gómez Montserrat
机构信息
Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel.li Domingo s/n 43007 Tarragona, Spain.
出版信息
Chem Commun (Camb). 2008 Dec 14(46):6197-9. doi: 10.1039/b813428f. Epub 2008 Oct 24.
The use of efficient Pd systems bearing C(2)-symmetric chiral diphosphite ligands derived from carbohydrates in asymmetric allylic substitution reactions is described here, reaching TOFs > 22 000 h(-1) in allylic alkylation and ca. 400 h(-1) in allylic amination, giving excellent enantioselectivities (ee > 99%) and kinetic resolution of the racemic substrate.
本文描述了在不对称烯丙基取代反应中使用带有源自碳水化合物的 C(2) 对称手性二亚磷酸酯配体的高效钯体系，在烯丙基烷基化反应中 TOF 大于 22000 h⁻¹，在烯丙基胺化反应中约为 400 h⁻¹，给出了优异的对映选择性（ee > 99%）以及外消旋底物的动力学拆分。
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