Balanta Castillo Angelica, Favier Isabelle, Teuma Emmanuelle, Castillón Sergio, Godard Cyril, Aghmiz Ali, Claver Carmen, Gómez Montserrat
Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel.li Domingo s/n 43007 Tarragona, Spain.
Chem Commun (Camb). 2008 Dec 14(46):6197-9. doi: 10.1039/b813428f. Epub 2008 Oct 24.
The use of efficient Pd systems bearing C(2)-symmetric chiral diphosphite ligands derived from carbohydrates in asymmetric allylic substitution reactions is described here, reaching TOFs > 22 000 h(-1) in allylic alkylation and ca. 400 h(-1) in allylic amination, giving excellent enantioselectivities (ee > 99%) and kinetic resolution of the racemic substrate.
本文描述了在不对称烯丙基取代反应中使用带有源自碳水化合物的 C(2) 对称手性二亚磷酸酯配体的高效钯体系，在烯丙基烷基化反应中 TOF 大于 22000 h⁻¹，在烯丙基胺化反应中约为 400 h⁻¹，给出了优异的对映选择性（ee > 99%）以及外消旋底物的动力学拆分。
