由2-芳基氨基-3-乙酰基-5,6-二氢-4H-吡喃高效合成环磷酰胺类似物及其发散合成
Efficient and divergent synthesis of cyclophosphamide analogues from 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans.
作者信息
Xiang Dexuan, Huang Peng, Wang Kewei, Zhou Guangyuan, Liang Yongjiu, Dong Dewen
机构信息
Department of Chemistry, Northeast Normal University, 130024, Changchun, China.
出版信息
Chem Commun (Camb). 2008 Dec 14(46):6236-8. doi: 10.1039/b815416c. Epub 2008 Oct 15.
DOI:10.1039/b815416c
PMID:19082131
Abstract
A facile and efficient one-pot synthesis of substituted cyclophosphamidic chlorides and their analogues has been developed from readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans.
摘要
从易得的烯胺酮、2-芳基氨基-3-乙酰基-5,6-二氢-4H-吡喃出发，开发了一种简便高效的一锅法合成取代环磷酰胺氯化物及其类似物的方法。
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