Prasad B A Bhanu, Gilbertson Scott R
Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555-0650, USA.
Org Lett. 2009 Aug 20;11(16):3710-3. doi: 10.1021/ol901189m.
An approach that provides symmetrical, unsymmetrical, and asymmetric N-heterocyclic carbene (NHC) ligands is reported. Reaction of iodoethanol with aniline provides N-(2-iodoethyl)arylamine salts that are then converted to the corresponding iodide. Reaction with aliphatic or aromatic amines followed by triethyl orthoformate was used to provide 26 different NHC ligands.
报道了一种提供对称、非对称和不对称N-杂环卡宾（NHC）配体的方法。碘乙醇与苯胺反应生成N-(2-碘乙基)芳胺盐，然后将其转化为相应的碘化物。与脂肪族或芳香族胺反应，随后用原甲酸三乙酯反应，用于制备26种不同的NHC配体。
