Al-Abdulhadi Saleh A, Al-Rabia Mohammed W
Department of Child Health, Royal Aberdeen Children's Hospital, University of Aberdeen, Medical School, Aberdeen, Scotland, United Kingdom.
Saudi Med J. 2008 Dec;29(12):1711-8.
To explore a possible association between the major functional CCR2V64I polymorphism and asthma and related phenotypes independent of atopy.
We conducted this study in the Royal Aberdeen Children's Hospital, University of Aberdeen Medical School, United Kingdom from September 2004 to December 2006. One hundred and fifty-four unrelated nuclear families (598 individuals including children and parents) were identified from the local Grampian population. The major functional polymorphism CCR2V64I was analyzed for associations with asthma, lung function (forced expiratory volume% [FEV1%] of predicted), bronchial hyperresponsiveness (BHR) to methacholine, total serum-immunoglobulin E (s-IgE) and allergic sensitization (positive skin prick test to common allergens) in 154 asthmatic families.
Pedigree disequilibrium test and case control analyses showed that the CCR2V64I polymorphism was significantly associated with the absence of asthma FEV1%, predicted above the population median of 83%, but not with s-IgE levels or specific sensitization.
We identified associations between the V-64I CCR2 polymorphism and protection against asthma, higher FEV1, and absence of BHR in families at high risk of asthma and atopy, suggesting an important role for the CCR2 receptor in modulating airway inflammation independent of atopy.
探讨主要功能性CCR2 V64I多态性与哮喘及相关表型之间可能存在的、独立于特应性的关联。
2004年9月至2006年12月，我们在英国阿伯丁大学医学院皇家阿伯丁儿童医院开展了这项研究。从当地格兰扁人群中识别出154个无血缘关系的核心家庭（包括儿童和父母在内共598人）。对154个哮喘家庭中的主要功能性多态性CCR2 V64I进行分析，以研究其与哮喘、肺功能（预计用力呼气量百分比[FEV1%]）、对乙酰甲胆碱的支气管高反应性（BHR）、血清总免疫球蛋白E（s-IgE）以及过敏致敏（对常见变应原皮肤点刺试验阳性）之间的关联。
系谱不平衡检验和病例对照分析表明，CCR2 V64I多态性与哮喘、高于人群中位数83%的预计FEV1%的缺失显著相关，但与s-IgE水平或特异性致敏无关。
我们发现CCR2 V-64I多态性与哮喘和特应性高风险家庭中预防哮喘、较高的FEV1以及无BHR之间存在关联，这表明CCR2受体在独立于特应性调节气道炎症方面发挥着重要作用。
