兔近端小管中β-丙氨酸转运体的化学计量学研究。
Stoichiometric studies of beta-alanine transporters in rabbit proximal tubule.
作者信息
Jessen H, Sheikh M I
机构信息
Institute of Medical Biochemistry, University of Aarhus, Denmark.
出版信息
Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):891-4. doi: 10.1042/bj2770891.
Abstract
The coupling ratio for the transport of beta-alanine and Na+, H+ and Cl- in luminal membrane vesicles isolated from proximal convoluted tubules (pars convoluta) and proximal straight tubules (pars recta) of rabbit kidney was examined. Indirect evidence indicates that 1 H+ and approx. 2 Na+, 1 Cl- (Na(+)-dependent, high-affinity) or 1 Na+ (Na(+)-dependent, low-affinity) are co-transported with beta-alanine in the pars convoluta. In pars recta, the two Na(+)-dependent transporters exhibited the same stoichiometric properties respectively as in pars convoluta.
摘要
研究了从兔肾近曲小管（曲部）和近端直小管（直部）分离的管腔膜囊泡中β-丙氨酸与Na⁺、H⁺和Cl⁻转运的偶联比率。间接证据表明，在近曲小管中，1个H⁺与大约2个Na⁺、1个Cl⁻（Na⁺依赖性、高亲和力）或1个Na⁺（Na⁺依赖性、低亲和力）与β-丙氨酸共转运。在近端直小管中，两种Na⁺依赖性转运体分别表现出与近曲小管相同的化学计量特性。
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