17R(18S)环氧二十碳四烯酸，一种20:5n-3在猴精囊中的细胞色素P-450代谢产物，被代谢为新型前列腺素。
17R(18S)epoxyeicosatetraenoic acid, a cytochrome P-450 metabolite of 20:5n-3 in monkey seminal vesicles, is metabolized to novel prostaglandins.
作者信息
Oliw E H
机构信息
Department of Pharmaceutical Pharmacology, Uppsala University Biomedical Centre, Sweden.
出版信息
Biochem Biophys Res Commun. 1991 Aug 15;178(3):1444-50. doi: 10.1016/0006-291x(91)91055-h.
Eicosapentaenoic acid (20:5n-3) is metabolized by cytochrome P-450w3 of monkey seminal vesicles to 17R(18S)epoxy-5,8,11,14-eicosatetraenoic acid (17R(18S)EpETE). PGH synthase is abundant in this tissue. Racemic 17(18)EpETE was therefore investigated as a substrate of PGH synthase. The main products were identified as two diastereoisomers of 17(18)epoxyprostaglandin E2, which were formed in a 4:5 ratio. The structures were confirmed by authentic material. The natural epoxide enantiomer can thus be metabolized to novel 17R(18S)epoxyprostaglandins.
二十碳五烯酸（20:5n-3）在猴精囊的细胞色素P-450w3作用下代谢为17R(18S) -环氧-5,8,11,14-二十碳四烯酸（17R(18S)EpETE）。PGH合酶在该组织中含量丰富。因此，外消旋17(18)EpETE被作为PGH合酶的底物进行研究。主要产物被鉴定为17(18) -环氧前列腺素E2的两种非对映异构体，其生成比例为4:5。结构经标准品确认。天然环氧化物对映体因此可代谢为新型17R(18S) -环氧前列腺素。
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