Liu Yu, Le Foll Bernard, Liu Yanli, Wang Xi, Lu Lin
National Institute on Drug Dependence, Peking University, Beijing, China.
ScientificWorldJournal. 2008 Dec 14;8:1228-45. doi: 10.1100/tsw.2008.154.
The conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking. The vast majority of studies have focused on CPP induced by illicit drugs, such as psychostimulants and opioids. Although legal psychoactive drugs, such as ethanol, nicotine, and caffeine, are more widely used than illegal drugs, the establishment, extinction, and reinstatement of CPP produced by these licit drugs are less well understood. The present review discusses the extant research on CPP induced by legal drugs. We first describe the CPP model and discuss the behavioral procedures used to induce CPP for ethanol, nicotine, and caffeine. We then summarize the neuronal substrates that underlie CPP induced by these drugs from a genetic perspective. Finally, we draw on findings from pharmacological studies and discuss the neurotransmitters and neurohormones underlying CPP produced by ethanol, nicotine, and caffeine.
条件性位置偏爱（CPP）模型已被广泛用于评估滥用药物的奖赏效应，最近，该范式的消退和复吸阶段已被用于评估药物寻求行为的复发。绝大多数研究都集中在非法药物（如精神兴奋剂和阿片类药物）诱导的CPP上。尽管合法的精神活性药物（如乙醇、尼古丁和咖啡因）的使用比非法药物更为广泛，但对于这些合法药物产生的CPP的建立、消退和复吸的了解却较少。本综述讨论了关于合法药物诱导CPP的现有研究。我们首先描述CPP模型，并讨论用于诱导乙醇、尼古丁和咖啡因CPP的行为程序。然后，我们从遗传学角度总结这些药物诱导CPP的神经元底物。最后，我们借鉴药理学研究的结果，讨论乙醇、尼古丁和咖啡因产生的CPP背后的神经递质和神经激素。
