Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China ; Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
Endocrinology Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
Evid Based Complement Alternat Med. 2014;2014:304718. doi: 10.1155/2014/304718. Epub 2014 Oct 29.
ASF composed by semen and epimedium herbal is a traditional plant compound that is widely used in the treatment of insomnia. Studies have shown that saponins and flavonoids contained in semen can significantly decrease the content of excitatory neurotransmitter Glu in mice. And the total flavone of YinYangHuo can increase the release of GABA in the anterior periventricular system of rat and increase the affinity of GABA for the receptors GABAA. It can be inferred that their synergism may have effect on the neurotransmitter that causes behavioral sensitization and conditioned place preference in experimental animals and affects their drinking behaviors, which is the starting point of this research. The present study found that ASF can inhibit development and expression of behavioral sensitization induced by ethanol and the development of CPP in mice. We demonstrate the inhibition of ASF on behavioral sensitization partly due to its effect on the mesolimbic neurotransmitter system, including decreasing level of DA and Glu and increasing the content of GABA. It suggested that the ASF may have pharmacological effects in the treatment of alcohol addiction.
由精液和淫羊藿组成的 ASF 是一种传统的植物化合物，广泛用于治疗失眠。研究表明，精液中的皂苷和黄酮类化合物可显著降低小鼠兴奋性神经递质 Glu 的含量。而阴阳火的总黄酮可以增加大鼠前室周系统中 GABA 的释放，并增加 GABA 对 GABAA 受体的亲和力。可以推断，它们的协同作用可能对实验动物引起行为敏感化和条件位置偏好的神经递质有影响，并影响它们的饮酒行为，这是本研究的起点。本研究发现，ASF 可抑制乙醇诱导的行为敏感化和小鼠 CPP 的发展。我们证明，ASF 对行为敏感化的抑制部分归因于其对中边缘神经递质系统的影响，包括降低 DA 和 Glu 的水平以及增加 GABA 的含量。这表明 ASF 可能在治疗酒精成瘾方面具有药理学作用。
