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Prompt remission of severe SLE with only three doses of rituximab infusion and low dose steroid: the first case report from Indonesia.

作者信息

Mardjuadi A, Soedirman M, Utoyo Buddy, Rasker J J

机构信息

Departments of Rheumatology, National Development University, Jakarta, Indonesia.

出版信息

Clin Rheumatol. 2009 Jun;28 Suppl 1:S27-30. doi: 10.1007/s10067-008-1069-8. Epub 2008 Dec 13.

DOI:10.1007/s10067-008-1069-8
PMID:19083076
Abstract

A 31-year-old Chinese lady presented with severe SLE with nephrotic syndrome, anemia, leucopenia and thrombocytopenia, skin lesions, and joint inflammation after failing previous standard therapy. After treatment with three infusions of rituximab she showed immediate improvements regarding clinical and laboratory parameters. She received no cytotoxic drugs and remained well for at least 7 months, despite stopping prednisolone.

摘要

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Prompt remission of severe SLE with only three doses of rituximab infusion and low dose steroid: the first case report from Indonesia.
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2
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本文引用的文献

1
Complete remission of lupus nephritis with rituximab and steroids for induction and rituximab alone for maintenance therapy.利妥昔单抗联合类固醇用于诱导治疗，利妥昔单抗单药用于维持治疗，狼疮性肾炎完全缓解。
Am J Kidney Dis. 2008 Aug;52(2):346-52. doi: 10.1053/j.ajkd.2008.03.036. Epub 2008 Jun 24.
2
Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus.抗CD20治疗对难治性系统性红斑狼疮患者的长期临床和免疫学影响。
J Rheumatol. 2008 May;35(5):826-33. Epub 2008 Apr 1.
3
Systemic lupus erythematosus.
系统性红斑狼疮
N Engl J Med. 2008 Feb 28;358(9):929-39. doi: 10.1056/NEJMra071297.
4
B-cell-directed therapies in systemic lupus erythematosus.系统性红斑狼疮中针对B细胞的疗法。
Semin Arthritis Rheum. 2008 Dec;38(3):218-27. doi: 10.1016/j.semarthrit.2007.11.003. Epub 2008 Feb 21.
5
Treatment of refractory SLE with rituximab plus cyclophosphamide: clinical effects, serological changes, and predictors of response.利妥昔单抗联合环磷酰胺治疗难治性系统性红斑狼疮：临床疗效、血清学变化及反应预测因素
Ann Rheum Dis. 2008 Mar;67(3):330-4. doi: 10.1136/ard.2007.079095. Epub 2007 Sep 7.
6
Progressive multifocal leukoencephalopathy in rheumatic diseases: evolving clinical and pathologic patterns of disease.风湿性疾病中的进行性多灶性白质脑病：疾病不断演变的临床和病理模式
Arthritis Rheum. 2007 Jul;56(7):2116-28. doi: 10.1002/art.22657.
7
New therapies for treatment of rheumatoid arthritis.类风湿关节炎的新疗法
Lancet. 2007 Dec 1;370(9602):1861-74. doi: 10.1016/S0140-6736(07)60784-3.
8
Histopathologic and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis.利妥昔单抗治疗对环磷酰胺耐药的增殖性狼疮性肾炎患者的组织病理学及临床结局
Arthritis Rheum. 2007 Apr;56(4):1263-72. doi: 10.1002/art.22505.
9
Therapy-resistent lupus skin disease successfully treated with rituximab.利妥昔单抗成功治疗难治性狼疮性皮肤病。
Rheumatology (Oxford). 2006 Jul;45(7):915-6. doi: 10.1093/rheumatology/kel162. Epub 2006 May 11.
10
Treatment of isolated severe immune hemolytic anaemia associated with systemic lupus erythematosus: 26 cases.系统性红斑狼疮相关的孤立性严重免疫性溶血性贫血的治疗：26例病例
Lupus. 2006;15(4):223-31. doi: 10.1191/0961203306lu2292oa.