Carr Timothy P, Jesch Elliot D, Brown Andrew W
Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583-0806, USA.
Nutr Res. 2008 Oct;28(10):641-50. doi: 10.1016/j.nutres.2008.08.003.
Understanding the endocannabinoid system as it relates to health and disease is a relatively new area of study. The discovery and cloning of cannabinoid receptors have prompted an increase in research aimed at identifying endogenous ligands ("endocannabinoids") and how these receptors and ligands regulate a variety of physiologic and pathologic events that include bone formation, the cardiovascular system, appetite control, and energy metabolism. With regard to nutrition, researchers have begun to ask whether the known effects of diet on metabolic processes are mediated through endocannabinoids and their receptors. Although only a few studies have been conducted that directly address the role of diet, results indicate that endocannabinoids can be regulated by eating frequency and by specific dietary components, particularly fatty acids. This review provides an overview of the endocannabinoid system and its control of metabolism, with emphasis on the impact of diet.
了解与健康和疾病相关的内源性大麻素系统是一个相对较新的研究领域。大麻素受体的发现和克隆促使了旨在识别内源性配体（“内源性大麻素”）以及这些受体和配体如何调节包括骨形成、心血管系统、食欲控制和能量代谢在内的各种生理和病理事件的研究增加。关于营养方面，研究人员已开始探讨饮食对代谢过程的已知影响是否通过内源性大麻素及其受体介导。尽管直接涉及饮食作用的研究仅有少数几项，但结果表明，内源性大麻素可受进食频率和特定饮食成分（尤其是脂肪酸）的调节。本综述概述了内源性大麻素系统及其对代谢的调控，重点阐述了饮食的影响。
