Farkas Jordan P, Richardson James A, Brown Spencer, Hoopman John E, Kenkel Jeffrey M
Department of Plastic Surgery-Clinical Center for Cosmetic Laser Treatment, University of Texas Southwestern Medical Center, Dallas, TX 75390-9132, USA.
Aesthet Surg J. 2008 Sep-Oct;28(5):503-11. doi: 10.1016/j.asj.2008.07.010.
BACKGROUND: Injectable hyaluronic acid fillers (HAFs) and laser/light procedures have become increasingly popular for noninvasive facial rejuvenation in many cosmetic practices. However, the effect of laser/light treatments on HAFs is unknown. OBJECTIVE: Our objective was to examine the effect of laser/light treatments on HAFs in a porcine model. METHODS: The abdomens of 6 Yorkshire pigs were injected with 3 different HAFs: Restylane (Medicis, Scottsdale, AZ), Perlane (Medicis), and Juvéderm (Allergan, Santa Barbara, CA). Two weeks after injection, the injection sites were treated with 1 of 7 common laser/light ablative or nonablative devices. Following laser treatment, 8-mm punch biopsies were collected from the treated tissue and fixed for histopathologic evaluation. Sections were stained with hematoxylin-eosin and alcian blue stains for identification of the preinjected HAF. RESULTS: The filler was identified in different areas of the dermis in different sections. The Sciton intense pulsed 560 nm filter (Sciton, Palo Alto, CA), the Sciton Nd: YAG, Lux1540 (Palomar Medical Technologies, Burlington, MA), or ActiveFX (Lumenis, Yokneum, Israel) treatments showed no sign of interaction with superficial or deep dermal filler. No evidence of morphologic changes to the filler or the surrounding tissues was observed. Obvious interaction between the HAFs and the laser injury was demonstrated in sections treated with the deep ablative systems fractional erbium 2940 (Profractional; Sciton) and DeepFX CO(2), (Lumenis). However, no uncharacteristic tissue injury or morphologic change in the filler was appreciated in any of the preinjected specimens. CONCLUSIONS: Injected HAFs were unaffected by the nonablative laser/light and superficial ablative treatments. The more aggressive deeper laser treatments demonstrated laser/filler interaction and may have a clinical effect on the longevity of the filler and/or efficacy of laser treatments. Novel ablative fractional lasers have the capability of deep dermal penetration, and this should be taken into consideration when planning to use them in combination with soft tissue fillers for noninvasive facial rejuvenation.
背景：在许多美容实践中，注射用透明质酸填充剂（HAF）和激光/光治疗已越来越多地用于非侵入性面部年轻化。然而，激光/光治疗对HAF的影响尚不清楚。 目的：我们的目的是在猪模型中研究激光/光治疗对HAF的影响。 方法：给6只约克夏猪的腹部注射3种不同的HAF：瑞蓝（Medicis，斯科茨代尔，亚利桑那州）、乔雅登雅致（Medicis）和乔雅登（艾尔建，圣巴巴拉，加利福尼亚州）。注射后两周，用7种常见的激光/光剥脱性或非剥脱性设备之一对注射部位进行治疗。激光治疗后，从治疗组织中采集8毫米打孔活检标本并固定，用于组织病理学评估。切片用苏木精-伊红和阿尔辛蓝染色，以识别预先注射的HAF。 结果：在不同切片的真皮不同区域发现了填充剂。Sciton强脉冲560纳米滤光片（Sciton，帕洛阿尔托，加利福尼亚州）、Sciton钕：钇铝石榴石、Lux1540（帕洛玛医疗技术公司，伯灵顿，马萨诸塞州）或ActiveFX（科医人，约克尼姆，以色列）治疗未显示与浅表或深部真皮填充剂有相互作用的迹象。未观察到填充剂或周围组织有形态学改变的证据。在使用深部剥脱系统分数铒2940（Profractional；Sciton）和DeepFX CO2（科医人）治疗的切片中，显示出HAF与激光损伤之间存在明显相互作用。然而，在任何预先注射的标本中，均未发现填充剂有异常组织损伤或形态学改变。 结论：注射的HAF不受非剥脱性激光/光和浅表剥脱性治疗的影响。更具侵袭性的深部激光治疗显示出激光/填充剂相互作用，可能对填充剂的持久性和/或激光治疗效果有临床影响。新型剥脱性分数激光具有深部真皮穿透能力，在计划将其与软组织填充剂联合用于非侵入性面部年轻化时应予以考虑。
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