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前瞻性临床试验证明透明质酸填充剂改善萎缩性面部瘢痕长达 2 年的疗效。

Prospective Clinical Trial Demonstrating the Efficacy of Hyaluronic Acid Filler for the Improvement of Atrophic Facial Scars up to 2 years.

机构信息

Florida Atlantic University, Boca Raton, Florida.

Siperstein Dermatology Group, Boynton Beach, Florida.

出版信息

Dermatol Surg. 2024 Dec 1;50(12):1143-1148. doi: 10.1097/DSS.0000000000004315. Epub 2024 Jul 5.

DOI:10.1097/DSS.0000000000004315
PMID:38968085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11594006/
Abstract

BACKGROUND: Hyaluronic acid (HA) filler longevity has been studied for wrinkles. However, its long-term use for treating atrophic facial scars has not yet been analyzed in long-term prospective studies. OBJECTIVE: Analyze the safety and duration of a HA filler for the use in atrophic scars. MATERIALS AND METHODS: Fifteen subjects received VYC-17.5L in atrophic scars on 1 randomized cheek and saline on the other, with 1 optional touch-up treatment and crossover after the short-term trial. Grading for this long-term extension was done on Day 720, using the Global Aesthetic Improvement Scale (GAIS) and the Quantitative Global Scarring Grading System. RESULTS: On Day 720, a live blind evaluator rated the VYC-17.5L assigned side as having significant reduction in scar severity (-7.2 [t(22) = -6.01, p = .00009]) and number of scars (-8.8 [t(22) = -6.25, p = .00006]) as compared with baseline. There was no significant difference in the results from Day 120 to Day 720. Ninety-two percent (11/12) of subjects reported improvement (GAIS), were satisfied with the treatment, thought it looked natural, and had fewer side effects than expected. There were no persistent or late-onset side effects. CONCLUSION: VYC-17.5L improved rolling atrophic facial scars, and the results were sustained throughout the 2-year trial without side effects.

摘要

背景：已有研究分析了透明质酸（HA）填充剂在皱纹方面的长效性，但尚未对其长期用于治疗萎缩性面部瘢痕进行长期前瞻性研究。 目的：分析 HA 填充剂治疗萎缩性瘢痕的安全性和持久性。 材料和方法：15 名受试者随机在一侧面颊接受 VYC-17.5L 治疗，另一侧接受生理盐水治疗，在短期试验后进行了 1 次可选的追加治疗和交叉。在第 720 天，使用全球美学改善量表（GAIS）和定量整体瘢痕分级系统对长期扩展进行分级。 结果：在第 720 天，一位盲法活体评估员对 VYC-17.5L 治疗侧的瘢痕严重程度评分（-7.2 [t(22) = -6.01，p =.00009]）和瘢痕数量评分（-8.8 [t(22) = -6.25，p =.00006]）与基线相比有显著降低。从第 120 天到第 720 天，结果没有显著差异。92%（11/12）的受试者报告改善（GAIS），对治疗满意，认为效果自然，且副作用比预期少。没有持续或迟发性副作用。 结论：VYC-17.5L 改善了滚动性萎缩性面部瘢痕，并且在 2 年的试验中没有副作用，结果持续存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8572/11594006/884157c11d1d/ds-50-1143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8572/11594006/884157c11d1d/ds-50-1143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8572/11594006/884157c11d1d/ds-50-1143-g001.jpg

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本文引用的文献

[1]
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Front Med (Lausanne). 2023-11-16

[2]
An Innovative Dual-Wavelength Laser Technique for Atrophic Acne Scar Management: A Pilot Study.

Medicina (Kaunas). 2023-11-15

[3]
From the Cochrane Library: Interventions for Acne Scars.

JMIR Dermatol. 2022-8-17

[4]
Efficacy and safety of fractional 1064-nm picosecond laser for atrophic traumatic and surgical scars: A randomized, single-blinded, split-scar-controlled study.

Lasers Surg Med. 2023-8

[5]
[Clinical effects of fractional carbon dioxide laser combined with minimally invasive scar release in the treatment of post-acne atrophic scars].

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023-1-20

[6]
To evaluate the efficacy and safety of laser interventions for facial acne scars: a systematic review and Bayesian network meta-analysis.

Ann Transl Med. 2022-12

[7]
A combined subcision approach with either fractional CO laser (10,600 nm) or cross-linked hyaluronic acid versus subcision alone in atrophic post-acne scar treatment.

Lasers Med Sci. 2022-12-24

[8]
Improvement in linear depressed atrophic scar using 755-nm picosecond alexandrite laser vs. ablative fractional carbon dioxide laser.

J Cosmet Laser Ther. 2022-7-4

[9]
A split-face, blind, randomized placebo-controlled clinical trial investigating the efficacy and safety of hyaluronic acid filler for the correction of atrophic facial scars.

J Cosmet Dermatol. 2022-9

[10]
[Clinical Observation of Recombinant Bovine Basic Fibroblast Growth Factor as an Adjuvant Therapy for Patients with Atrophic Acne Scar].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022-4

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