Bauer M
Institute of Legal Medicine, University of Bonn, Bonn, Germany.
Forensic Sci Int Genet. 2007 Mar;1(1):69-74. doi: 10.1016/j.fsigen.2006.11.002. Epub 2007 Jan 8.
RNA analysis offers insight into diseases and mechanisms leading to death and could develop into a valuable tool for diagnosis of the cause of death in forensic pathology. Other possible applications include the determination of the age of wounds and injuries and of the post-mortem interval. The molecular identification of body fluids by analysis of cell-specific mRNA expression already represents a new technique supplementing DNA analysis in forensic cases. This review explains and discusses principles, techniques and applications by offering a complete and comprehensive overview of research results in forensic RNA work.
RNA分析有助于深入了解导致死亡的疾病和机制,并有可能发展成为法医病理学中诊断死亡原因的宝贵工具。其他可能的应用包括确定伤口和损伤的时间以及死后间隔时间。通过分析细胞特异性mRNA表达对体液进行分子鉴定,已成为法医案件中补充DNA分析的一项新技术。本综述通过全面概述法医RNA研究成果,对相关原理、技术和应用进行了解释和讨论。