Institute of Forensic Medicine, University of Bonn, Bonn, Germany.
Forensic Sci Int. 2010 Dec 15;203(1-3):3-14. doi: 10.1016/j.forsciint.2010.07.017. Epub 2010 Aug 21.
Techniques of molecular biology have improved diagnostic sensitivity, accuracy and validity in forensic medicine very much, especially in the field of identification (paternity testing, stain analysis). Since more than 10 years these techniques - meanwhile well established in clinical disciplines - are used also for other applications in forensic medicine: determination of cause and manner of death, tissue identification by mRNA and microRNA, examination of gene expression levels (survival time, time since death, cause of death), toxicogenetics.
分子生物学技术极大地提高了法医学诊断的敏感性、准确性和有效性,尤其是在鉴定领域(亲子关系鉴定、污渍分析)。这些技术在临床学科中已经得到了很好的应用,已经有 10 多年的历史了,它们也被用于法医学的其他应用:确定死因和死亡方式、通过 mRNA 和 microRNA 进行组织鉴定、检查基因表达水平(存活时间、死亡时间、死亡原因)、毒物遗传学。