Chen Feng, Wang Sha-Yan, Zhang Ruan-Zhang, Hu Yu-Hua, Gao Guo-Feng, Liu Yan-Hui, Kong Qing-Peng
Shenzhen People's Hospital, Clinical Medical College of Jinan University, Shenzhen, China.
Forensic Sci Int Genet. 2008 Mar;2(2):150-3. doi: 10.1016/j.fsigen.2007.10.122.
Previous investigations on Chinese mitochondrial DNA (mtDNA) variation revealed that the matrilineal gene pool of southern Han Chinese is rather complex, with much higher genetic diversity and more basal/ancient lineages than the northern Hans. The extreme case is Guangdong Han populations, among which pronounced (matrilineal) differentiation has been observed, indicative of complex demography of the region. To get more insights into the maternal makeup of southern Han Chinese, mtDNA variation of a total of 106 individuals sampled from Dongguan, Guangdong Province, China, was analyzed in this study. With the aid of the information from control-region hypervariable segments I and II (HVS-I and -II) as well as some necessary coding-region segments, the phylogenetic status of all mtDNAs under examination were determined according to the reconstructed East Asian mtDNA tree. In this way, the mtDNAs have been classified into various haplogroups or sub-haplogroups. The southern-prevalent haplogroups, such as R9 (20.8%), B (17.9%), M7b (14.2%), show relatively high distribution frequencies in Dongguan Hans; whereas the frequencies of Northern-prevalent haplogroups (with the exception of D) are quite low: C (1.9%), G2 (1.9%) and Z (1.9%), indicating the southern-origin of Dongguan Hans.
先前对中国线粒体DNA（mtDNA）变异的研究表明，南方汉族的母系基因库相当复杂，其遗传多样性远高于北方汉族，且拥有更多的基部/古老谱系。极端的例子是广东汉族群体，在这些群体中观察到了显著的（母系）分化，这表明该地区人口结构复杂。为了更深入了解南方汉族的母系构成，本研究分析了从中国广东省东莞市采集的106个个体的mtDNA变异。借助控制区高变区I和II（HVS-I和-II）以及一些必要的编码区片段的信息，根据重建的东亚mtDNA树确定了所有检测mtDNA的系统发育地位。通过这种方式，mtDNA被分为不同的单倍群或亚单倍群。在东莞汉族中，南方常见的单倍群，如R9（20.8%）、B（17.9%）、M7b（14.2%），显示出相对较高的分布频率；而北方常见单倍群（除D外）的频率相当低：C（1.9%）、G2（1.9%）和Z（1.9%），这表明东莞汉族起源于南方。
