淋巴细胞迁移的缩放方面。
Scaling aspects of lymphocyte trafficking.
作者信息
Perelson Alan S, Wiegel Frederik W
机构信息
Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
出版信息
J Theor Biol. 2009 Mar 7;257(1):9-16. doi: 10.1016/j.jtbi.2008.11.007. Epub 2008 Nov 18.
Abstract
We consider the long lived pool of B and T cells that recirculate through blood, tissues and the lymphatic system of an animal with body mass M. We derive scaling rules (allometric relations) for: (1) the rate of production of mature lymphocytes, (2) the accumulation of lymphocytes in the tissues, (3) the flux of lymphocytes through the lymphatic system, (4) the number of lymph nodes, (5) the number of lymphocytes per clone within a lymph node, and (6) the total number of lymphocytes within a lymph node. Mass-dependent aspects of immune learning and of the immunological self are shown to be not very significant. Our treatment is somewhat heuristic and aims at combining immunological data with recent progress in biological scaling.
摘要
我们研究了在体重为M的动物体内，通过血液、组织和淋巴系统循环的长寿B细胞和T细胞库。我们推导了以下方面的标度律（异速生长关系）：（1）成熟淋巴细胞的产生速率；（2）组织中淋巴细胞的积累；（3）淋巴细胞通过淋巴系统的通量；（4）淋巴结的数量；（5）每个淋巴结内每个克隆的淋巴细胞数量；（6）一个淋巴结内淋巴细胞的总数。免疫学习和免疫自我中与质量相关的方面显示不太显著。我们的处理方法有点启发式，旨在将免疫学数据与生物标度方面的最新进展相结合。
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