Tucci Valter, Plazzi Giuseppe
MRC Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD Oxfordshire, UK.
Neurosci Lett. 2009 Jan 30;450(2):90-1. doi: 10.1016/j.neulet.2008.11.060. Epub 2008 Dec 6.
Narcolepsy, cataplexy and emotions form an intriguing triad that fascinates sleep researchers. A novel aspect of narcoleptic patients' behaviours now appears depending on the emotional valence of the context: how can we explain the fact that narcoleptic patients may experience pleasant-triggered (e.g. laughing) cataplexy as well as unpleasant-related drawback performance (Tucci, V., Stegagno, L., Vandi, S., Ferrillo, F., Palomba, D., Vignatelli, L., Ferini-Strambi, L., Montagna, P., Plazzi, G., Emotional information processing in patients with narcolepsy: a psychophysiologic investigation, Sleep 26 (2003) 558-564; Khatami, R., Birkmann, S., Bassetti, C.L., Amygdala dysfunction in narcolepsycataplexy, J. Sleep Res. 16 (2007) 226-229)? With this in mind we postulate that narcolepsy with cataplexy is a complex sleep disorder that, among others, affects the modulation of emotions at different levels: structural, cellular and molecular.
发作性睡病、猝倒症与情绪构成了一个吸引睡眠研究人员的有趣三联体。发作性睡病患者行为的一个新方面现在似乎取决于情境的情绪效价：我们如何解释发作性睡病患者可能会经历由愉悦引发的（如大笑）猝倒以及与不愉快相关的行为缺陷这一事实（图奇，V.，斯特加诺，L.，万迪，S.，费里洛，F.，帕洛马，D.，维尼亚泰利，L.，费里尼 - 斯特兰比，L.，蒙塔纳，P.，普拉齐，G.，发作性睡病患者的情绪信息处理：一项心理生理学调查，《睡眠》26（2003）558 - 564；哈塔米，R.，伯克曼，S.，巴西蒂，C.L.，发作性睡病 - 猝倒症中的杏仁核功能障碍，《睡眠研究杂志》16（2007）226 - 229）？考虑到这一点，我们推测伴猝倒的发作性睡病是一种复杂的睡眠障碍，除其他外，它会在不同层面影响情绪调节：结构、细胞和分子层面。
