左心室收缩末期容积指数对稳定型冠状动脉疾病患者心力衰竭住院的预测价值：来自“心灵研究”的数据
Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: data from the Heart and Soul Study.
作者信息
McManus David D, Shah Sanjiv J, Fabi Mary Rose, Rosen Alisa, Whooley Mary A, Schiller Nelson B
机构信息
Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143, USA.
出版信息
J Am Soc Echocardiogr. 2009 Feb;22(2):190-7. doi: 10.1016/j.echo.2008.11.005. Epub 2008 Dec 11.
Abstract
OBJECTIVE
Left ventricular (LV) end-systolic volume indexed to body surface area (ESVI) is a simple yet powerful echocardiographic marker of LV remodeling that can be measured easily. The prognostic value of ESVI and its merit relative to other markers of LV remodeling in patients with coronary heart disease are unknown.
METHODS
We examined the association of ESVI with hospitalization for heart failure (HF) and mortality in a prospective study of patients with coronary heart disease.
RESULTS
Of the 989 participants, 110 (11%) were hospitalized for HF during 3.6 +/- 1.1 years of follow-up. Among participants in the highest ESVI quartile (> 25 mL/m(2)), 67 of 248 (27%) developed HF compared with 8 of 248 (3%) among those in the lowest quartile. The association between ESVI and HF hospitalization persisted after adjustment for potential confounders (hazard ratio 5.0, 95% confidence interval, 1.5-16.9; P = .01).
CONCLUSION
ESVI > 25 mL/m(2) is an independent predictor of hospitalization for HF in patients with stable coronary heart disease.
摘要
目的
左心室收缩末期容积指数（ESVI）是一种简单却有效的左心室重构超声心动图指标，易于测量。ESVI的预后价值及其相对于冠心病患者左心室重构其他指标的优势尚不清楚。
方法
在一项冠心病患者前瞻性研究中，我们检测了ESVI与心力衰竭（HF）住院及死亡率之间的关联。
结果
在989名参与者中，110名（11%）在3.6±1.1年的随访期间因HF住院。在ESVI最高四分位数组（>25 mL/m²）的参与者中，248名中有67名（27%）发生HF，而在最低四分位数组中，248名中有8名（3%）发生HF。在对潜在混杂因素进行调整后，ESVI与HF住院之间的关联仍然存在（风险比5.0，95%置信区间，1.5 - 16.9；P = 0.01）。
结论
ESVI>25 mL/m²是稳定型冠心病患者HF住院的独立预测因子。
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