用于心肌梗死的靶向纳米级治疗药物
Targeted nanoscale therapeutics for myocardial infarction.
作者信息
Sullivan Holly L, Gianneschi Nathan C, Christman Karen L
机构信息
Department of Bioengineering and Sanford Consortium for Regenerative, Medicine, University of California, San Diego, La Jolla, USA.
出版信息
Biomater Sci. 2021 Feb 21;9(4):1204-1216. doi: 10.1039/d0bm01677b. Epub 2020 Dec 23.
Abstract
Nanoscale therapeutics have promise for the administration of therapeutic small molecules and biologics to the heart following myocardial infarction. Directed delivery to the infarcted region of the heart using minimally invasive routes is critical to this promise. In this review, we will discuss the advances and design considerations for two nanoscale therapeutics engineered to target the infarcted heart, nanoparticles and adeno-associated viruses.
摘要
纳米级疗法有望在心肌梗死后将治疗性小分子和生物制剂输送到心脏。通过微创途径将药物定向输送到心脏梗死区域对于实现这一前景至关重要。在本综述中，我们将讨论两种经设计用于靶向梗死心脏的纳米级疗法——纳米颗粒和腺相关病毒的进展及设计考量。
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