Takahashi Naoto, Hasegawa Hisaya, Komiyama Mami, Ohki Takehiro, Yada Yukari, Koike Yasunori, Kawamata Ryou, Honma Yoko, Momoi Mariko
Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken 329-0498, Japan.
Cytokine. 2009 Jan;45(1):39-43. doi: 10.1016/j.cyto.2008.10.015. Epub 2008 Dec 11.
Neonatal toxic shock syndrome (TSS)-like exanthematous disease (NTED) is an emerging neonatal infectious disease caused by TSS toxin-1 (TSST-1). Although NTED and TSS are caused by the same superantigenic exotoxin, NTED is less severe than TSS. The mechanism of this reduced severity in NTED has not been elucidated. Thirteen patients with NTED were enrolled in the study. We investigated serum cytokine profile using a cytometric bead array system with a cytokine panel. Expression of Vbeta2 and CD45RO in CD4(+) T cells was investigated in mononuclear cells by using flowcytometry. Ten patients with other bacterial infections and eight patients without any infections were also enrolled as control groups. The mean serum level of IL-10 was 1209.9 pg/mL in patients with NTED at the time of admission into the study. The other inhibitory cytokine, IL-4, exhibited a minimum level. The high level of IL-10 rapidly decreased within 3-9 days of the onset of NTED. The cytokine profile of NTED, with its high IL-10 level, was clearly different from that of the other bacterial infections. The increased level of IL-10 seems to be related to the reduced severity of NTED. Th2 shift is not thought to be the cause of this IL-10 excretion.
新生儿中毒性休克综合征（TSS）样疹病（NTED）是一种由TSS毒素-1（TSST-1）引起的新出现的新生儿感染性疾病。尽管NTED和TSS由相同的超抗原性外毒素引起，但NTED的严重程度低于TSS。NTED严重程度降低的机制尚未阐明。本研究纳入了13例NTED患者。我们使用细胞因子检测板的细胞计数珠阵列系统研究血清细胞因子谱。通过流式细胞术在单核细胞中研究CD4(+) T细胞中Vbeta2和CD45RO的表达。另外10例其他细菌感染患者和8例无任何感染的患者也作为对照组纳入研究。在纳入本研究时，NTED患者的血清IL-10平均水平为1209.9 pg/mL。另一种抑制性细胞因子IL-4水平最低。NTED发病后3 - 9天内，高水平的IL-10迅速下降。NTED的细胞因子谱，其IL-10水平较高，与其他细菌感染的细胞因子谱明显不同。IL-10水平升高似乎与NTED严重程度降低有关。Th2偏移不被认为是这种IL-10分泌的原因。
