Skuse David H, Gallagher Louise
Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Trends Cogn Sci. 2009 Jan;13(1):27-35. doi: 10.1016/j.tics.2008.09.007. Epub 2008 Dec 10.
A well-mapped set of brain regions is dedicated to social cognition. It is responsive to social cues, engaged in moral decision-making and makes predictions about the likely behaviour of other people. Recent studies of affiliation, using animal models, have revealed that specific neurotransmitters and hormones influence the neural circuits of 'the social brain'. There is converging evidence that the interface between the neuropeptides oxytocin and vasopressin and dopaminergic reward circuits is of particular importance. In the context of recent research, we discuss emerging evidence for the impact of these neuropeptides on the regulation of the social brain. We also examine the putative role of allelic variation in candidate genes on individual differences in social cognitive processing and associated social behaviour.
一组映射良好的脑区专门负责社会认知。它对社会线索有反应，参与道德决策，并对他人可能的行为进行预测。最近利用动物模型进行的关于亲密关系的研究表明，特定的神经递质和激素会影响“社会脑”的神经回路。越来越多的证据表明，神经肽催产素和加压素与多巴胺能奖赏回路之间的相互作用尤为重要。结合最近的研究，我们讨论了这些神经肽对社会脑调节影响的新证据。我们还研究了候选基因中的等位基因变异在社会认知加工个体差异及相关社会行为中的假定作用。
