老年人丙型肝炎：流行病学、自然史及治疗
Hepatitis C in the elderly: epidemiology, natural history, and treatment.
作者信息
Mindikoglu Ayse L, Miller Ram R
机构信息
Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland 21201-1595, USA.
出版信息
Clin Gastroenterol Hepatol. 2009 Feb;7(2):128-34; quiz 124. doi: 10.1016/j.cgh.2008.07.017. Epub 2008 Dec 12.
Abstract
Hepatitis C continues to be a major public health problem affecting approximately 3% of the global population. According to the World Health Organization, an estimated 170 million people have chronic hepatitis C. Ten percent to 20% of those who are chronically infected with hepatitis C will progress to cirrhosis and 5% will develop hepatocellular carcinoma. Although the safety and efficacy of hepatitis C therapies have been studied extensively in patients between the ages of 18 and 65, patients who are older than 65 still remain an understudied and difficult-to-treat population. This review discusses the epidemiology, natural history, and treatment of chronic hepatitis C in older adults.
摘要
丙型肝炎仍然是一个重大的公共卫生问题，影响着全球约3%的人口。据世界卫生组织估计，有1.7亿人患有慢性丙型肝炎。慢性丙型肝炎感染者中有10%至20%会发展为肝硬化，5%会发展为肝细胞癌。尽管丙型肝炎治疗方法的安全性和有效性已在18至65岁的患者中进行了广泛研究，但65岁以上的患者仍然是研究不足且难以治疗的人群。本综述讨论了老年人慢性丙型肝炎的流行病学、自然史和治疗方法。
相似文献
1
Hepatitis C in the elderly: epidemiology, natural history, and treatment.老年人丙型肝炎：流行病学、自然史及治疗
Clin Gastroenterol Hepatol. 2009 Feb;7(2):128-34; quiz 124. doi: 10.1016/j.cgh.2008.07.017. Epub 2008 Dec 12.
2
Treatment of hepatitis B and C in children.儿童乙型和丙型肝炎的治疗。
Minerva Pediatr. 2014 Oct;66(5):473-89.
3
[Chronic hepatitis C: initial treatment in patients without previous treatment].慢性丙型肝炎：既往未接受过治疗患者的初始治疗
Gastroenterol Hepatol. 2002 May;25(5):347-55. doi: 10.1016/s0210-5705(02)79037-7.
4
[Management of sarcoidosis-associated chronic hepatitis C virus infection: course and treatment].[结节病相关慢性丙型肝炎病毒感染的管理：病程与治疗]
Rev Clin Esp. 2009 Jul-Aug;209(7):358-9. doi: 10.1016/s0014-2565(09)71824-7.
5
[Goals of treatment, indication, and treatment for chronic hepatitis C].[慢性丙型肝炎的治疗目标、适应证及治疗]
Korean J Gastroenterol. 2008 Jun;51(6):368-71.
6
[Indication of monotherapy with pegylated interferon or interferon for patient with HCV in Japan].[聚乙二醇干扰素或干扰素单药治疗日本丙型肝炎病毒患者的适应证]
Nihon Rinsho. 2011 May;69 Suppl 4:185-9.
7
Peginterferon plus ribavirin versus interferon plus ribavirin for chronic hepatitis C.聚乙二醇干扰素联合利巴韦林与干扰素联合利巴韦林治疗慢性丙型肝炎的比较
Cochrane Database Syst Rev. 2014 Feb 28;2014(2):CD005441. doi: 10.1002/14651858.CD005441.pub3.
8
Developments in the treatment of chronic hepatitis C.慢性丙型肝炎治疗的进展
Expert Opin Investig Drugs. 2002 Apr;11(4):515-28. doi: 10.1517/13543784.11.4.515.
9
Viral hepatitis C.丙型病毒性肝炎
Lancet. 2003 Dec 20;362(9401):2095-100. doi: 10.1016/s0140-6736(03)15109-4.
10
Advances in therapy for chronic hepatitis C.慢性丙型肝炎治疗进展
Clin Liver Dis. 2001 Nov;5(4):1009-23. doi: 10.1016/s1089-3261(05)70206-3.
引用本文的文献
1
Safety and efficacy of directly-acting antiviral therapy for chronic hepatitis C virus in elderly people.直接作用抗病毒疗法治疗老年人慢性丙型肝炎病毒感染的安全性和有效性
Aging Med (Milton). 2021 Dec 21;4(4):304-316. doi: 10.1002/agm2.12190. eCollection 2021 Dec.
2
Influential Factors of Successful Hepatitis C Treatment in Elderly Patients.老年患者丙型肝炎治疗成功的影响因素
Innov Pharm. 2019 Sep 19;10(3). doi: 10.24926/iip.v10i3.2144. eCollection 2019.
3
High prevalence of occult hepatitis C infection in predialysis patients.透析前患者中隐匿性丙型肝炎感染的高患病率。
World J Hepatol. 2019 Jan 27;11(1):109-118. doi: 10.4254/wjh.v11.i1.109.
4
Association of sustained virologic response with reduced progression to liver cirrhosis in elderly patients with chronic hepatitis C.老年慢性丙型肝炎患者持续病毒学应答与肝硬化进展减缓的关联
Clin Interv Aging. 2016 Mar 17;11:327-34. doi: 10.2147/CIA.S97242. eCollection 2016.
5
Burden of Hepatitis C Virus Infection Among Older Adults in Long-Term Care Settings: a Systematic Review of the Literature and Meta-Analysis.长期护理机构中老年丙型肝炎病毒感染负担：文献系统评价与荟萃分析
Curr Infect Dis Rep. 2016 Mar;18(4):13. doi: 10.1007/s11908-016-0518-9.
6
Liver physiology and liver diseases in the elderly.老年人的肝脏生理学和肝脏疾病。
World J Gastroenterol. 2013 Dec 14;19(46):8459-67. doi: 10.3748/wjg.v19.i46.8459.
7
Hepatitis C virus and lichen planus: the real association.丙型肝炎病毒与扁平苔藓：真正的关联
Hepat Mon. 2010 Summer;10(3):161-4. Epub 2010 Sep 1.
本文引用的文献
1
Efficacy of ribavirin plus interferon-alpha in patients aged >or=60 years with chronic hepatitis C.利巴韦林联合α干扰素治疗60岁及以上慢性丙型肝炎患者的疗效
J Gastroenterol Hepatol. 2007 Jul;22(7):989-95. doi: 10.1111/j.1440-1746.2006.04773.x.
2
The effect of age on response to therapy with peginterferon alpha plus ribavirin in a cohort of patients with chronic HCV hepatitis including subjects older than 65 yr.年龄对聚乙二醇干扰素α联合利巴韦林治疗一组慢性丙型肝炎病毒（HCV）肝炎患者（包括65岁以上受试者）疗效的影响
Am J Gastroenterol. 2007 Jul;102(7):1383-91. doi: 10.1111/j.1572-0241.2007.01201.x. Epub 2007 Mar 31.
3
Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients.对干扰素治疗产生持续病毒学应答的慢性丙型肝炎患者肝细胞癌的发生情况：一项针对1124例患者的多中心回顾性队列研究。
Liver Int. 2007 Mar;27(2):186-91. doi: 10.1111/j.1478-3231.2006.01406.x.
4
Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C.老年慢性丙型肝炎患者干扰素治疗后的长期疗效
Intervirology. 2007;50(1):16-23. doi: 10.1159/000096308.
5
Elderly patients are at greater risk of cytopenia during antiviral therapy for hepatitis C.老年患者在丙型肝炎抗病毒治疗期间发生血细胞减少的风险更高。
Can J Gastroenterol. 2006 Sep;20(9):589-92. doi: 10.1155/2006/357259.
6
Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease?6865例65岁及以上患者的丙型肝炎：一种严重且被忽视的可治愈疾病？
Am J Gastroenterol. 2006 Jun;101(6):1260-7. doi: 10.1111/j.1572-0241.2006.00556.x.
7
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002.1999年至2002年美国丙型肝炎病毒感染的流行情况。
Ann Intern Med. 2006 May 16;144(10):705-14. doi: 10.7326/0003-4819-144-10-200605160-00004.
8
Are elderly patients poor candidates for pegylated interferon plus ribavirin in the treatment of chronic hepatitis C?老年患者是否不适宜采用聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎？
J Am Geriatr Soc. 2006 Mar;54(3):549-50. doi: 10.1111/j.1532-5415.2006.00643_4.x.
9
Efficacy of interferon therapy in elderly patients with chronic hepatitis C.干扰素治疗老年慢性丙型肝炎患者的疗效
Intervirology. 2006;49(3):121-6. doi: 10.1159/000089372.
10
Limitation of combination therapy of interferon and ribavirin for older patients with chronic hepatitis C.干扰素与利巴韦林联合治疗老年慢性丙型肝炎患者的局限性。
Hepatology. 2006 Jan;43(1):54-63. doi: 10.1002/hep.20984.
Zotero 插件