So Ju-Hoon, Chun Hang-Suk, Bae Yong-Ki, Kim Hyun-Seo, Park Yeoll-Mae, Huh Tae-Lin, Chitnis Ajay B, Kim Cheol-Hee, Yeo Sang-Yeob
Department of Biology, Chungnam National University, Daejeon, Republic of Korea.
Biochem Biophys Res Commun. 2009 Jan 30;379(1):22-6. doi: 10.1016/j.bbrc.2008.11.149. Epub 2008 Dec 11.
Transcripts of notch and its target genes have been detected in some differentiating neurons. However, the role of Notch in neuronal differentiation remains poorly defined. Here, we show that a subset of differentiating sensory neurons in the trigeminal ganglia express her4. Expression of her4 requires Notch signaling during neurogenesis but not during differentiation, when peripheral projections of the trigeminal ganglia are established. These projections develop poorly in her4 morphants. While many components of the canonical Notch signaling pathway are not required for late her4 expression or peripheral axon outgrowth in trigeminal neurons, simultaneous knock-down of Notch receptors prevents establishment of these peripheral projections. These observations suggest that Her4 and Notch play a role in peripheral outgrowth of sensory neurons.
在一些正在分化的神经元中已检测到Notch及其靶基因的转录本。然而，Notch在神经元分化中的作用仍不清楚。在此，我们表明三叉神经节中一部分正在分化的感觉神经元表达her4。her4的表达在神经发生过程中需要Notch信号传导，但在三叉神经节的外周投射建立时的分化过程中则不需要。这些投射在her4 morphants中发育不良。虽然经典Notch信号通路的许多成分对于三叉神经元中her4的晚期表达或外周轴突生长不是必需的，但同时敲低Notch受体会阻止这些外周投射的建立。这些观察结果表明，Her4和Notch在感觉神经元的外周生长中起作用。
