Groh-Bordin Christian, Glocker Daniela, Bittl Petra, Keller Ingo, Preger Rudolf, Hildebrandt Helmut, Kerkhoff Georg
Clinical Neuropsychology Unit, Saarland University, Saarbruecken, Germany.
Neuropsychologia. 2009 Mar;47(4):1187-92. doi: 10.1016/j.neuropsychologia.2008.11.018. Epub 2008 Nov 24.
Body representational neglect (BRN) and apraxia can be found after left hemisphere (LH) lesions. Additionally, both disorders recruit knowledge about certain body parts, their position in space, and their spatial relationship to each other. Hence, the present study examined whether BRN and apraxia can be functionally dissociated at the behavioral and neural level. 23 LH lesioned patients were examined with a standardized body neglect test (Vest test) and a standardized test of apraxia (imitation of meaningless gestures). At the behavioral level BRN and apraxia showed a double dissociation. Moreover, these deficits were associated with specific brain lesions: while BRN was related to lesions in Brodmann areas 6 and 44 and frontal white matter, apraxia was linked to lesions in the superior longitudinal fasciculus and parietal and central white matter. The results are discussed as indicating dissociable representations of the human body within the left cerebral hemisphere.
身体表征忽视（BRN）和失用症可在左半球（LH）损伤后出现。此外，这两种障碍都需要关于某些身体部位、它们在空间中的位置以及它们彼此之间空间关系的知识。因此，本研究考察了BRN和失用症在行为和神经水平上是否在功能上可分离。对23名左半球损伤患者进行了标准化的身体忽视测试（韦氏测试）和标准化的失用症测试（模仿无意义手势）。在行为水平上，BRN和失用症表现出双重分离。此外，这些缺陷与特定的脑损伤有关：BRN与布罗德曼6区和44区以及额叶白质的损伤有关，而失用症与上纵束以及顶叶和中央白质的损伤有关。讨论结果表明在左脑半球内人体存在可分离的表征。
