Thompson Martin
Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA.
Biochimie. 2009 Mar;91(3):309-19. doi: 10.1016/j.biochi.2008.10.019. Epub 2008 Dec 3.
The human Polybromo-1 protein (Pb1) was recently identified as a unique subunit of the PBAF (Polybromo, Brg1-Associated Factors) chromatin-remodeling complex required for kinetochore localization during mitosis and the transcription of estrogen-responsive genes. Pb1 coordinates key features common to all remodeling complexes, including chromatin localization, recruitment of protein subunits and alteration of chromatin architecture. A comprehensive analysis of individual domains composing Pb1 is used to propose new information regarding the function of Pb1 in the PBAF chromatin-remodeling complex. The newly identified regulatory role of this important protein is also examined to explain both native function and the emerging role of Pb1 as a tumor suppressor found to be mutated in breast cancer.
人类多溴蛋白-1（Pb1）最近被确定为PBAF（多溴、Brg1相关因子）染色质重塑复合体的一个独特亚基，该复合体在有丝分裂期间着丝粒定位和雌激素反应基因的转录过程中是必需的。Pb1协调所有重塑复合体共有的关键特征，包括染色质定位、蛋白质亚基的募集以及染色质结构的改变。对组成Pb1的各个结构域进行全面分析，以提出有关Pb1在PBAF染色质重塑复合体中功能的新信息。还研究了这种重要蛋白质新确定的调节作用，以解释其天然功能以及Pb1作为在乳腺癌中发现发生突变的肿瘤抑制因子的新出现作用。
