Wagner Jan, Elger Christian E, Urbach Horst, Bien Christian G
Department of Epileptology, University of Bonn, Bonn, Germany.
Epilepsy Behav. 2009 Feb;14(2):425-8. doi: 10.1016/j.yebeh.2008.11.006. Epub 2008 Dec 11.
Gray matter heterotopia are a common cause of pharmacoresistant epilepsy. Recently, several case studies have addressed the question of whether heterotopia can contribute to physiological cerebral functions. We describe two cases that demonstrate a functional role for periventricular heterotopia in higher cognitive processes. During presurgical diagnostics, two patients underwent electric stimulation of both the periventricular heterotopia and the overlying cortex. This revealed a functional role of periventricular heterotopia in higher cerebral functions such as language and complex visual and acoustic processing. Furthermore, stimulation of the overlying cortex led to unusually intense positive phenomena, including complex acoustic and gustatory hallucinations and language production. These cases illustrate that periventricular heterotopic neurons can contribute to higher cerebral functions. Interestingly, the anterior-to-posterior representation of these functions is comparable to the normal anterior-to-posterior representation in a normal neocortex (similar to a periventricular "minicortex" in early developmental stages).
灰质异位是药物难治性癫痫的常见病因。最近，一些病例研究探讨了异位是否能对生理性脑功能产生影响。我们描述了两例病例，这些病例证明了脑室周围异位在高级认知过程中的功能作用。在术前诊断期间，两名患者接受了对脑室周围异位和上方皮质的电刺激。这揭示了脑室周围异位在诸如语言以及复杂的视觉和听觉处理等高级脑功能中的功能作用。此外，对上方皮质的刺激导致了异常强烈的阳性现象，包括复杂的听觉和味觉幻觉以及语言产生。这些病例表明脑室周围异位神经元可对高级脑功能有贡献。有趣的是，这些功能从前到后的表现与正常新皮质中正常的从前到后的表现相当（类似于发育早期的脑室周围“微型皮质”）。
