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[Wells' cellulitis and bacterial necrotizing cellulitis induced by anakinra].

作者信息

Livory M, Wechsler J, Revuz J, Bagot M, Chevalier X, Poszepczynska-Guigné E

机构信息

Service de dermatologie, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.

出版信息

Ann Dermatol Venereol. 2008 Dec;135(12):839-42. doi: 10.1016/j.annder.2008.02.026. Epub 2008 Aug 3.

DOI:10.1016/j.annder.2008.02.026
PMID:19084694
Abstract

BACKGROUND

Anakinra is a recombinant form of the naturally occurring human interleukin-1 receptor antagonist. It is used in the treatment of rheumatoid arthritis. The most frequent side effects are injection site reactions, which seem to have a toxic mechanism.

PATIENTS AND METHODS

We report two unusual cases of injection site reactions with anakinra: a woman presented Wells' cellulitis of the thigh and a man developed serious bacterial cellulitis distinguished by deep necrosis at the site of the latest anakinra subcutaneous injection.

DISCUSSION

The cases are examples of serious side effects that can occur during treatment with anakinra and underline the need for careful use of this new biological agent.

摘要

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[Wells' cellulitis and bacterial necrotizing cellulitis induced by anakinra].
Ann Dermatol Venereol. 2008 Dec;135(12):839-42. doi: 10.1016/j.annder.2008.02.026. Epub 2008 Aug 3.
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