尼古丁和Δ⁹-四氢大麻酚戒断会诱导杏仁核中央核中的Narp产生。
Nicotine and Delta(9)-tetrahydrocannabinol withdrawal induce Narp in the central nucleus of the amygdala.
作者信息
Reti Irving M, Han Sungho, Miskimon Matthew, Rosen Jeffrey B, Baraban Jay M
机构信息
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21205, USA.
出版信息
Synapse. 2009 Mar;63(3):252-5. doi: 10.1002/syn.20586.
The central nucleus of the amygdala plays a key role in mediating aversive responses to drug withdrawal, effects thought to contribute to continued drug use. In previous studies, we found that the immediate early gene Narp, which encodes a secreted protein that binds to AMPA receptors, is induced in this nucleus following opiate withdrawal. Furthermore, Narp deletion alters the acquisition and extinction of aversive conditioning induced by opiate withdrawal. We now report that Narp is also induced in the central nucleus following withdrawal from other drugs of abuse, nicotine and Delta(9)-tetrahydrocannabinol, indicating that Narp is a common component of the transcriptional response triggered by drug withdrawal.
杏仁核中央核在介导对药物戒断的厌恶反应中起关键作用，这些反应被认为会导致持续用药。在先前的研究中，我们发现即刻早期基因Narp（其编码一种与AMPA受体结合的分泌蛋白）在阿片类药物戒断后会在该核中被诱导表达。此外，Narp基因缺失会改变阿片类药物戒断诱导的厌恶条件反射的获得和消退。我们现在报告，在从其他滥用药物（尼古丁和Δ⁹-四氢大麻酚）戒断后，Narp也会在中央核中被诱导表达，这表明Narp是药物戒断引发的转录反应的一个共同组成部分。
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