Baptiste-Roberts Kesha, Salafia Carolyn M, Nicholson Wanda K, Duggan Anne, Wang Nae-Yuh, Brancati Frederick L
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J Matern Fetal Neonatal Med. 2009 Jan;22(1):13-23. doi: 10.1080/14767050802415728.
We hypothesised that the gross placental measures would be positively associated with childhood growth.
We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7.
Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (beta = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (beta = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: beta = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005).
Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.
我们假设胎盘的总体测量指标与儿童生长呈正相关。
我们分析了参与围产期协作项目的23967对母婴的数据。在按种族分层的回归模型中，主要结局指标为出生体重以及4岁和7岁时的体质指数（BMI）z评分。
一些胎盘测量指标与7岁时的BMI z评分显著相关：在黑人中，胎盘重量（β = 0.0004/g；95%置信区间：0.0001，0.0008）、绒毛膜板面积（β = 0.0007；95%置信区间：0.0001，0.0012）和最大直径（β = 0.013；95%置信区间：0.004，0.026）；在白人中，胎盘重量（β = 0.0004/g；95%置信区间：0.0001，0.0003）和最大直径（模型3：β = 0.020；95%置信区间：0.007，0.032）。作为一个整体进行检验时，胎盘测量指标显著预测了7岁时的BMI z评分（所有p值<0.005）。
胎盘结构可独立预测出生体重和儿童生长。改善胎盘结构的策略可能会对出生体重和儿童发育产生有利影响。
