Khaira Mandip, Mutamba Antony, Meligonis George, Rose Geoffrey E, Plowman Piers N, O'Donnell Helen
Department of Medical Oncology, St. Bartholomew's Hospital, London, UK.
Orbit. 2008;27(6):432-7. doi: 10.1080/01676830802350216.
To describe two patients with localized orbital amyloidosis and the response of their condition to surgical debulking followed by external beam radiotherapy.
Retrospective noncomparative interventional case series.
Stabilization or regression of orbital signs after treatment.
Patients with biopsy-proven diagnosis of localized progressive orbital amyloidosis received 34 and 30 Gy fractionated external beam radiotherapy. The clinical case notes and histopathology for the two patients were reviewed.
A 69-year-old man with orbital amyloid deposition in association with localized MALT lymphoma had a marked improvement in orbital signs following surgical debulking and radiotherapy, with no recurrence over two years. A 59-year-old woman with localized orbital amyloidosis showed regression of disease after surgical debulking and radiotherapy, with no evidence of recurrence after six years of follow-up.
External beam radiotherapy following surgical debulking appears to halt the progression of localized orbital amyloidosis. Radiotherapy may be used in conjunction with surgical debulking of disease.
描述两名局限性眼眶淀粉样变性患者及其病情对手术减瘤后外照射放疗的反应。
回顾性非对照干预病例系列。
治疗后眼眶体征的稳定或消退。
经活检证实为局限性进行性眼眶淀粉样变性的患者接受了34Gy和30Gy的分次外照射放疗。回顾了这两名患者的临床病例记录和组织病理学。
一名69岁男性眼眶淀粉样沉积伴局限性黏膜相关淋巴组织淋巴瘤，手术减瘤和放疗后眼眶体征明显改善，两年内无复发。一名59岁女性局限性眼眶淀粉样变性患者，手术减瘤和放疗后病情消退，随访六年无复发迹象。
手术减瘤后外照射放疗似乎可阻止局限性眼眶淀粉样变性的进展。放疗可与疾病的手术减瘤联合使用。
