Gregory Ralph
Neuroscience Unit, John Radcliffe Hospital, Oxford, UK.
Br J Neurosurg. 2008;22 Suppl 1:S13-5. doi: 10.1080/02688690802448343.
Subthalamic deep brain stimulation is now well established as a treatment for the dopaminergic motor symptoms of Parkinson's disease. It has little effect on postural instability and "on-state" gait freezing. Animal experiments and early human pilot studies suggest that Pedunculopontine nucleus stimulation may alleviate these phenomenon, consistent with the hypothesis that these disabling symptoms are secondary to degeneration in non-dopaminergic pathways.
丘脑底核深部脑刺激现已被确认为治疗帕金森病多巴胺能运动症状的有效方法。它对姿势不稳和“开期”步态冻结几乎没有效果。动物实验和早期人体试验研究表明，脚桥核刺激可能会缓解这些现象，这与这些致残症状是由非多巴胺能通路退变继发产生的假说相符。
