Kekkaku. 1991 May;66(5):367-73.
As a part of the epidemiological surveillance for the resistance to anti-tuberculosis drugs in pulmonary tuberculosis patients, successive surveys of the prevalence of resistance to tuberculosis drugs were conducted by Tuberculosis Research Committee "Ryoken". The prevalence of drug resistance according to the sensitivity test at local laboratories was reported as follows from the results of the ninth survey conducted in 1982. 1. In 1957, the percentage of the patients without history of previous chemotherapy among the newly admitted patients to hospital was only 17.8%, but it increased in each survey reaching 64.2% in 1982. 2. According to the results of sensitivity tests at local institutions, the prevalence of initial resistance to at least one of SM, INH and/or PAS was 13.6%, and that to each of the drug was 8.8%, 4.2% and 5.1%, respectively. 3. Prevalence of acquired resistance to at least one of SM, INH and/or PAS among newly admitted patients with history of previous treatment was 54.0% in 1957, and it increased in each survey reaching 65.4% in 1963. Since then, it decreased gradually, and became 40.1% in 1982. Decrease in the prevalence of acquired resistance was statistically confirmed.
作为肺结核患者抗结核药物耐药性流行病学监测的一部分，结核病研究委员会“Ryoken”连续开展了结核病药物耐药率调查。根据当地实验室药敏试验结果，1982年进行的第九次调查所报告的耐药率如下：1. 1957年，新入院患者中无既往化疗史的患者比例仅为17.8%，但在每次调查中均有所上升，1982年达到64.2%。2. 根据当地机构的药敏试验结果，对链霉素（SM）、异烟肼（INH）和/或对氨基水杨酸（PAS）中至少一种药物的初始耐药率为13.6%，对每种药物的耐药率分别为8.8%、4.2%和5.1%。3. 有既往治疗史的新入院患者中，对链霉素、异烟肼和/或对氨基水杨酸中至少一种药物的获得性耐药率在1957年为54.0%，在每次调查中均有所上升，1963年达到65.4%。此后逐渐下降，1982年降至40.1%。获得性耐药率的下降得到了统计学证实。
